Identification of Pyrrolidinophenone-type Designer Drugs by Gas Chromatography/Time-of-Flight Mass Spectrometry
Journal Title: Journal of Forensic Science & Criminology - Year 2014, Vol 2, Issue 6
Abstract
Use of gas chromatography (GC) combined with time-of –flight mass spectrometry (TOFMS) with soft ionization generated with three different plasma gases (i.e., Xe, Kr, Ar) was evaluated for the identification of several pyrrolidinophenone-type designer drugs that are commercially available. Surprisingly, the mass spectra obtained with soft ionization exhibited only the immonium ions and lacked the molecular ions just like with 70 eV electron ionization. However, use of derivatization with 1-methyl-1-phenylhydrazine and soft ionization of the hydrazones with Ar plasma at 11.61/11.82 eV provides information that is helpful in structure elucidation. This paper focuses on the soft ionization of the hydrazones of 2,3-methylenedioxypyrovalerone (MDPV) and its deuterated analog containing eight deuterium atoms on the pyrrolidine ring, to establish a fragmentation pathway for the soft ionization of such compounds when using GC-TOFMS.
Authors and Affiliations
Lopez-Avila V
Keywords
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- EP ID EP586066
- DOI 10.15744/2348-9804.2.301
- Views 107
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