Identification of Strain H41-55 and Chemical Constituents from its Fermentation Broth
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 5
Abstract
The strain H41-55 was identified as Streptomyces antibioticus according to morphological, cultural, and physiological and biochemical characteristics in combination with 16S rDNA sequence and phylogenetic tree analysis of the strain, and the 16S rDNA accession number in Genbank was FJ702547. Five steroid and two actinomycin compounds, named ergosta-7,22-diene-3b,5a,6b-triol (1), ergosta-8 (14),22E-diene-3b,5a,6b,7a-tetraol (2), 3b,5a,9a-trihydroxy-(22E,24R)-ergosta-7,22-diene-6-one (3), ergosta-4,6,8 (14),22-tetraen-3-one (4) and (22E,24R )-ergosta-4,7,22-trien-3-one (5), actinomycin D (6), actinomycin X2 (7), were isolated from the fermentation broth of strain H41-55. The structures of the steroid were determined by spectroscopic methods including NMR and MS as well as comparison with the data of literatures.
Authors and Affiliations
Xiansheng Li, Birun Lin, Guangxiong Zhou
Keywords
Related Articles
- EP ID EP432712
- DOI -
- Views 106
- Downloads 0
Quality-Adjusted Life Years (QALYs) of Tuberculosis Patients in the Intensive and Continuous Phase in a Private Hospital of Yogyakarta, Indonesia
Context Tuberculosis is a disease with low quality of life (QoL) and quality-adjusted life years (QALYs) due to illness, impairment of health conditions and death. QALYs combine the QoL as well as quantity of life with v...
Isolation and Identification of Antioxidant Flavonoids from the Seeds of Cardiocrinum Giganteum var. Yunnanense
One new biflavonoid, 3″-hydroxyrobustaflavone (1), together with four known compounds (2-5) were isolated from the seeds of Cardiocrinum giganteum var. yunnanense. The new structure was elucidated based on the extensive...
In vitro Antifungal Activity of Pluronic-based Thermo-Sensitive Itraconazole Gels for Vaginal Administration
Vulvovaginal candidiasis (VVC) is a common genital disease disturbing women. ITZ is widely used for the treatment of VVC by oral administration in clinic. Due to its irregular absorption and systematic side effects, loca...
Effects of Aqueous Root Extract of Annona Senegalensis on Bitisarietans Venom Protease and Phospholipase A2 Activities
The aqueous root extract of Annona senegalensis was investigated for its inhibitory activity towards Bitisarietans venom protease and phospholipase A2 activity (PLA2). The activities of protease and phospholipase A2 (V0)...
Toxicity Induced by Madopar (l-DOPA) during Curing Parkinson’s Disease by Inhibiting Mitochondrial Function and AKT Pathway
Madopar is an effective drug being used clinically for curing Parkinson’s disease (PD) nowadays. However, a growing number of studies found that the Madopar has a falling trend in curative effect including dyskinesia and...