IDENTIFYING DRUG-DRUG INTERACTION AMONG CHRONIC KIDNEY DISEASE PATIENTS IN TERTIARY CARE HOSPITAL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 7
Abstract
Drug-drug interactions (DDIs) are common in clinical practice and are directly related to factors such as polypharmacy, aging, hepatic metabolism and decreased renal function. Individuals with chronic kidney disease (CKD) often require multiple classes of drugs being at important risk for the development of DDIs. The objectives of this study were to identify the drug-drug interactions in CKD patients admitted to medicine ward in KIMS Hospital & Research Centre, and to categorize the drug-drug interactions based on their severity. The prescriptions of 108 patients who fulfilled inclusion criteria of study were analyzed during the study period to determine drug-drug interactions (DDIs). Out of total patient included in the study, in 78 patients medical record, 388 DDIs has been found during patient`s medical record analysis. On correlating between patient`s age group and DDIs it has been found that most number of recorded DDIs, 33 patients (30.56%) were belong to age group between 51-70 years. DDIs has been classified into serious, significant and minor. Out of total 388 DDIs, 57 (14.96%), 220 (56.7%) and 111 (28.61%) were serious, significant and minor DDIs respectively. Among all prescribed drugs, diuretics were among drugs with highest number of DDIs followed by antihypertensive agents, hypoglycemia agents and antithrombotic agents respectively. In relationship between polypharmacy and DDIs the highest number of patients, 48 (44.44%) have been received 13-17 medications. Patients with renal insufficiency are at high risk of drug-drug interactions, especially in the later stages of the disease. Monitoring patient`s medication chart by clinical pharmacist to detect DDIs early can improve quality of patient health care and provide appropriate mechanism for management of drug therapy among CKD patients.
Authors and Affiliations
Yasaman Ghanbari, Kiran Nagaraju
Keywords
Related Articles
- EP ID EP107199
- DOI 10.7897/2230-8407.07785
- Views 100
- Downloads 0
ANALGESIC EFFECT OF THE ETHANOLIC EXTRACT OF MORINGA OLEIFERA LINN. PLANT ON INDUCED ALBINO MICE
The ethanolic extract of whole part of Moringa oleifera plant in Eddy’s Hot plate method shows markedly increase in the pain threshold of mice. The three different Extract Curative doses of 100 mg/kg, 200 mg/kg and 400 m...
CASE STUDY: EFFECT OF AYURVEDIC IN RHEUMATOID ARTHRITIS
Rheumatoid arthritis is an autoimmune disease that can cause chronic inflammation of the joints and may involve other areas of the body. Rheumatoid arthritis can cause permanent joint destruction and deformity. Rheumatoi...
DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL SULPHATE
Prime object of present study was to develop and evaluate mucoadhesive tablets of Salbutamol Sulphate by non aqueous granulation of polymers HPMC K-4M (Hydroxypropyl Methyl Cellulose) and Chitosan in different ratios (1:...
SOME TRADITIONALLY USED ANTI-ARTHRITIC HERBS A REVIEW
Arthritis is one of the major problems in older age. There are about as many herbal remedies for arthritis as there are arthritis sufferers. Most work by improving the circulation, and encourage fluid elimination. Inflam...
NONSURGICAL MANAGEMENT OF ABSCESS OF THE SPLEEN IN GERIATRIC PATEINT: CASE REPORT AND REVIEW OF LITERATURE
In this case report, we present an event of a 65-year-old man with a diagnosed that, increased spleen size 120×90mm with two hypo echoic lesions with areas of cystic degeneration of sizes of 45×36mm (35 ml) noted in uppe...