IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis
Journal Title: Annals of Hepatology - Year 2013, Vol 12, Issue 3
Abstract
[b]Background[/b]. IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem to correlate with hepatic dysfunction intensity. Aims. To investigate the significance of IGF-I and IGFBP-3 in patients with decompensated liver disease. [b]Material and methods[/b]. Cross-sectional study that included cirrhotic patients admitted to hospital due to complications of the disease, in whom IGF-I and IGFBP-3 serum levels were measured by chemiluminescence. [b]Results[/b]. Seventy-four subjects with a mean age of 53.1 ± 11.6 years were included in the study, 73% were males. IGF-I levels were positively correlated with IGFBP-3 and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR and aPTT ratio. IGFBP-3 levels were positively correlated with IGF-I and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR, total bilirubin and aPTT ratio. Significantly lower scores of IGF-I and IGFBP-3 were observed in patients with higher MELD values and higher Child-Pugh classes (P < 0.05). [b]Conclusions[/b]. In cirrhotic patients admitted to hospital due to complications of the disease, IGF-I and IGFBP-3 serum levels were associated with variables related to liver dysfunction and to more advanced liver disease. The levels of these markers seem to undergo little influence from other clinical and laboratory variables, therefore mainly reflecting hepatic functional status.
Authors and Affiliations
Marcelo Ronsoni, Cesar Lazzarotto, Leonardo Fayad, Mariana Silva, Christiane Nogueira, Maria Bazzo, Janaína Narciso-Schiavon, Esther Dantas-Corrêa, Leonardon de Lucca Schiavon
Keywords
Related Articles
- EP ID EP78285
- DOI -
- Views 136
- Downloads 0
Surgical morbidity in severely obese liver transplant recipients - A single Canadian Centre Experience
The prevalence of obesity is increasing globally, with nearly half of a billion of the world’s population now considered to be overweight or obese. Obesity and overweight patients are one of the major health issues in Ca...
Fibrogenic/Angiogenic Linker for Non-Invasive Assessment of Hepatic Fibrosis Staging in Chronic Hepatitis C Among Egyptian Patients
Background and rationale for the study. Liver biopsy is the golden standard for staging liver fibrosis, but it may be accompanied by complications. Because of this complication, the aim of this study is to evaluate a sim...
Defining renal failure in cirrhosis –Acute kidney injury classification or traditional criteria?
Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress
This review addresses recent and not so recent works that emphasize on the mechanisms by which liver damage can induce encephalopathy. Hepatic encephalopathy constitutes an intriguing complication in severe liver acute a...
Hepatoprotective effect of pentoxifylline against D-galactosamine-induced hepatotoxicity in rats
The present study was conducted to investigate effect of pentoxifylline (PTX) on acute liver injury caused by galactosamine (D-Gal) in rats and the underlying mechanism involved in this setting. Moreover, we attempted to...