IKBKE GENE-A NEWLY POTENTIAL THERAPEUTIC TARGET FOR TREATING NON-SMALL CELL LUNG CANCER
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 3
Abstract
The IKBKE gene is part of a family of enzyme complexes involved in increasing cellular inflammation. IKBKE over expression has been associated with breast and prostate cancers. However, it had not been linked to environmental carcinogen, such as tobacco smoke, until now. Tobacco smoke is the strongest documented initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.
Authors and Affiliations
Gaurav Singh*| Department of Pharmacology, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007, Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074, Anil Kumar Gupta| Research Scholar, Bhagwant University, Institute of Pharmacy & Research Center, Ajmer, Rajasthan, India-305004, Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Sojitra Ishita| Department of Pharmaceutics, Parul Institute of Pharmacy, Vadodra, Gujarat, India- 391760, Bhupender Nimbiwal| Department of Quality Assurance, Seth G. L. Bihani S. D. College of Technical Education, IPSDR, Sri Ganganagar, Rajasthan, India-335001, Garima Bharti| Department of Physiology, Bhojia Dental College and Hospital, Nalagarh Road, Budh, Baddi, Himachal Pradesh, India-173205
Keywords
Related Articles
- EP ID EP1366
- DOI -
- Views 536
- Downloads 30
Drug Addiction in Vindhyan Population of Madhya Pradesh: a Socio-economic and Health Perspective
In Indian society the problem of intoxication, inebriation is a faster growing bug. This bug mostly grab illiterate person, socially enigmatic person, unemployed person, workers and laborers which leads to serious health...
Journal of Drug Discovery and Therapeutics 2 (22) 2014, 01-06
The review provides scientific and basics view on radiocarbon dating. However, his presentation, calibration and interpretation of radiocarbon ages are misleading in some cases, and important wide applications for age de...
Emerging drug discovery paradigm in non small cell lung cancer: pharmacophore modeling, atom-based 3D- QSAR and virtual screening of novel EGFR inhibitors
EGFR is a significant drug target approached in the domain of the wide prevailing cancer type, non- small cell lung cancer and search for its potent inhibitor is an emerging opportunity in cancer drug discovery. Computat...
DERMAL TRANSPORT OF MACRO-MOLECULE MEDICINES
These delivery techniques may be perfect; they do have numerous weaknesses when contrasted with infusions. For instance, oral administration requires proficient assimilation through the gastrointestinal (GI) tract. In th...
INVESTIGATION OF IN VITRO ANTHELMINTIC ACTIVITY OF FICUS ELASTICA LEAVES
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. The increasing of anthelmintic drug resistance and the high cost of anthelmintic drugs led to the development...