IL-17A and IL-23 cytokines and their relation with estrogen in post menopausal osteoporosis
Journal Title: International Journal of Orthopaedics Sciences - Year 2018, Vol 4, Issue 1
Abstract
Introduction: Estrogen deficiency is now considered as post inflammatory state as it has been associated with elevation of various cytokines like IL-1 IL-6 and TNF-α, responsible for osteoclastogenesis. Role of IL-17 has been established in various inflammatory and auto-immune disorders associated with bone loss, we evaluated the levels of IL-17 with respect to estrogen in post menopausal women with and without osteoporosis. Material & Methods: Total 75 post menopausal females with mean age (58.17±5.94), between age group 45-75years were recruited. Females with history of natural menopause at least one year after the onset of menopause were enrolled. All patients underwent BMD measurement through Dual energy X-ray absorptiometry (DEXA) scan and divided into two groups, Group A patients with osteoporosis and Group B without osteoporosis. Serum level of IL-17, IL-23 levels and Estrogen level were measured by standard quantitative sandwich ELISA kits. Results: Group A patients level of IL-17(48.49±8.34 pg/ml) and IL-23(91.28±9.89 pg/ml) was significantly higher than in group B patients with level of IL-17(19.55±7.11 pg/ml), IL-23 (44.56±11.36 pg/ml) while that of estrogen was significantly low in group A (31.80±12.57 pg/ml) in comparison to group B (40.39±20.88 pg/ml). Conclusion: We observed lower level of estrogen is associated with higher level of inflammatory cytokines IL-17 and IL-23, thus further strengthening the concept that post menopausal osteoporosis is inflammatory disorder as estrogen deficiency results in elevation of inflammatory cytokines.
Authors and Affiliations
Shah Waliullah, Vineet Sharma, RN Srivastava, Yashodhara Pradeep, AA Mahdi, Santosh Kumar
Keywords
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- EP ID EP485560
- DOI 10.22271/ortho.2018.v4.i1m.124
- Views 112
- Downloads 0
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