IL-1β and TNF-α as a biomarker of recurrence in malignant eyelid tumors
Journal Title: IP International Journal of Ocular Oncology and Oculoplasty - Year 2016, Vol 2, Issue 3
Abstract
Aim: To establish a correlation between cytokine levels (IL-1β, TNF-α and IL-10) and establishing them as a biomarker of recurrence in malignant eyelid tumors. Materials and Methods: Prospective observational cross-sectional case-control study of 38 consecutive cases of malignant eyelid tumors that underwent surgical treatment over a period of 18 months. 26 age and sex matched controls with other non-inflammatory, non- neoplastic eyelid disorders. The levels of the cytokines [IL-1β (Interleukin- 1β), TNF-α (Tumor necrosis factor-α), IL-10 (Interleukin-10)] (in pg/ml) were determined by using ELISA Kit. Data was analyzed statistically. Result: On comparing the mean cytokine levels of the two groups, t-test revealed significantly higher levels of IL- 1β (16.39±2.86 vs. 14.62±3.72, t=2.17, p=0.034), TNF-α (19.32±3.47 vs. 16.74±4.45, t=2.61, p=0.011) and IL-10 (24.79±5.87 vs. 21.61 ± 4.61, t=2.33, p=0.023) in cases. ANOVA revealed significantly different levels of IL- 1β (F=7.86, p<0.001), TNF-α (F=7.42, p<0.001) and IL-10 (F=4.36, p=0.006) between tumor and it’s three adjacent tissues. Conclusion: Cytokine levels (IL-1β, TNF-α and IL-10) in the adjacent tissues beyond safety margins were normal and comparable to that in controls suggesting the margins to be tumor free. Highly significant lower levels of IL-1β and TNF-α in tissues beyond safety margins can be used as an important predictor for local recurrence of tumor.
Authors and Affiliations
Khalida Sayeed, Apjit Kaur, SK Bhasker, AB Pant
Keywords
Related Articles
- EP ID EP243642
- DOI -
- Views 120
- Downloads 0
Oculo-orbital developmental disorders
Developmental disorders of orbit or its contents may occur occasionally as an isolated anomaly or more often gates associated with other nervous system malformations or may occur as part of multisystem syndrome. It inclu...
A cross - sectional study of the visual profile of pituitary macroadenomas in a tertiary health care
Pituitary Macroadenoma primarily a benign neurological condition initially may present to the Ophthalmologist with loss of vision This cross sectional study in a Tertiary Health Care involved the analysis of the visual p...
To study and evaluate the efficacy of amniotic membrane graft with conformer compared with mucous membrane graft with conformer in mild to moderate contracted socket
Aim To evaluates the efficacy of both amniotic membrane transplantation and mucous membrane graft with conformer in each group in fornix reconstruction in mild to moderate contracted socketMaterials and Methods This stud...
Clinicopathological study of ocular surface squamous neoplasia in non-HIV patients and effect of topical cyclosporine
Introduction: Ocular Surface Squamous Neoplasia is a spectrum of conjunctival and corneal epithelial neoplasia manifesting as dysplasia, carcinoma-in-situ and squamous cell carcinoma. Study was aimed to know the clinicop...
Ophthalmic artery occlusion following lateral orbitotomy
Visual loss following orbital surgery though rare is a devastating complication Ophthalmic artery occlusion as a cause is even more rare and grave as the vision loss is irreversible We report one such case following late...