Immobilization-induced increases of systolic blood pressure and dysregulation of electrolyte balance in ethanol-treated rats
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 4
Abstract
Clinical and experimental studies revealed that alcohol drinking and life event stresses are predisposing factors to hypertension. Intra and extra cellular levels of electrolytes may play important role in the pathogenesis and treatment of hypertension. Dietary intake of sodium, potassium, calcium and magnesium is suggested to have a role in the regulation of blood pressure. The present study was designed to monitor the effects of acute exposure to 2h immobilization stress and ethanol administration at a dose of 2.5g/kg body weight (i.p.) and combined effect of acute administration of ethanol and immobilization stress on systolic blood pressure (SBP), intraerythrocyte, serum and tissue electrolytes in rats. Results showed that acute exposure to 2h immobilization increased SBP, intraerythrocyte sodium and decreased intraerythrocyte potassium in water as well as in ethanol injected rats. The concentration of Na+ and Ca2+ increased while that of K+ and Mg2+ decreased in the heart and kidney tissue. Ethanol administration also increased Na+ and Ca2+levelsand decreased K+ and Mg2+ levels in the heart and kidney tissue. Restraint stress decreased serum levels of Na+, K+, Ca2+, P, and Cl – and increased serum Mg2+, glucose and haematocrit. Ethanol administration also decreased serum levels of Na+, K+, Ca2+, P, and Cl – and increased serum Mg2+, glucose and haematocrit. The effects of ethanol and stress on the changes of blood and tissues electrolytes were additive and may be involved in the greater occurrence of hypertension in alcoholics. Our results suggested an important role of intra and extra cellular electrolytes in both stress and ethanol-induced hypertension. The findings may help to develop strategies for the treatment of hypertension in alcoholics.
Authors and Affiliations
Farzana Yasmin , Zeba Haque , Huma Ikram , Darakhshan Jabeen Haleem
Keywords
Related Articles
- EP ID EP148369
- DOI -
- Views 106
- Downloads 0
Investigation of VIM, IMP, NDM-1, KPC AND OXA-48 enzymes in Enterobacteriaceae strains
Gram-negative bacteria especially Enterobacteriaceae species have become an increasing etiologic agent of nosocomial infections. The development of resistance to carbapenems have become an increasing problem in the...
Formulation and in vitro release studies of pegylated mucin based matrix tablets
The effects of polymer concentration on the flow properties of granules and in-vitro release profiles from matrix tablets of three model drugs formulated from pegylated mucin base was investigated. Mucin was extrac...
The effects of new polyherbal Unani formulation AJMAL06 on serum creatinine level in chronic renal failure
This study was conducted to evaluate the efficacy of Unani Ajmal06, an herbal formulation for management of chronic renal failure (CRF). The therapeutic evaluations of three different formulations such as Itrifal K...
Preliminary antioxidant profile of Pistacia integerrima Stewart
To explore the free radical scavenging properties of crude ethanolic extract of galls, bark, leaves, roots of Pistacia integerrima and its subsequent solvent fractions viz., n-hexane, chloroform, ethyl acetate and...
Effects of curcumine on antioxidation in diabetic rats
To investigate the effects of curcumin on antioxidation and its mechanism in diabetic rat model. After streptozotocin (STZ) induced diabetic rat model, large, medium and small doses of curcumin group were partly gi...