Immuno-epidemiology and Transmission Characteristics of SARS-CoV-2: A Perspective Investigation
Journal Title: Journal of Clinical Immunology & Microbiology - Year 2021, Vol 2, Issue 2
Abstract
Coronaviruses propagate efficiently within the heterogeneous population of humans to disperse infections. For Severe Acute Respiratory Syndrome Coronavirus-2 the determination of the heterogeneity of individual infectiousness is an appropriate way for immune-epidemiology investigation due to the cross reactive immunity of general population to coronaviruses. In this perspective investigation it is aimed to understand how SARS-COV-2 transmits within the human population that overwhelming evidence show that has an a priori trained immunity against SARS-COV-2 and a long lasting immunity against SARS-CoV-1. Using a sample of population in a close geographical proximity to the initial SARS-CoV-1 outbreak, we explored the association between infector’s age and dispersion (or heterogeneity) of individual infectiousness (k) in order to investigate the relatedness with the age of an individual’s capability to disperse the disease in the initial outbreak of SARS-CoV-2 in China. Importantly, we have found a negative association between k and increase of infector’s age. Significantly this became more evident for the age group of 20-40 years comparing with the infectors with younger and older ages. In this respect, a thorough analysis of the role of acquired adaptive machinery of receptor recognition that during various immunity statuses of the hosts propagate efficiently the infection within a heterogeneous population was carried out. Finally, the special relations of continuous positive viral adaptations of coronavirus infections that pre-program the immune conditions of infected hosts within the general population were analyzed.
Authors and Affiliations
Anthony M Kyriakopoulos*, Kyriaki Karafyllidou, Jinhui Li, Shi Zhao
Keywords
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- EP ID EP699098
- DOI http://dx.doi.org/10.46889/JCIM.2021.2201
- Views 97
- Downloads 0
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