Immunohistochemistry to Detect Ki-67 ,ER and PR in Iraqi Breast Cancer Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Background:Ki67 (cell proliferation marker) has been attracting a considerable attention as a prognostic factor in breast cancer. Objective: To investigate expression and significance of ER, PR and Ki67 in breast cancer, and analyze the influence on judging prognosis. Method :Immunohistochemistry was employed to detect expression of ER,PR and Ki67 in benign lesions of breast(11 cases) and malignant breast cancer(62cases). All cases were admitted to Al-Yarmouk teaching Hospital, Baghdad Medical City,between December 1999-January2001 Results : Positive rates of ER,PR and Ki67 were 27.2%,45.0%,63.6% respectively in benign lesions of breast. Positive rates of the expression of ER,PR and Ki67 in malignant breast cancer were 37.1%,51.6%and 40.3 % respectively. Poorly Differentiated Ductal Carcinoma) PDC (occupied the highest percentage (50%) for expression of ki-67. Conclusion: The expression rates of ER, PR and Ki67 in cancer are obviously higher than those in non- www.jmscr.igmpublication.org Impact Factor 1.1147 ISSN (e)-2347-176x Nidhal Abdul Mohaimen JMSCR Volume 2 Issue 6 June 2014 Page 1561 JMSCR Volume||2||Issue||6||Page 1560-1570||June 2014 2014 cancer tissue. In PDC, the expression of Ki67 is higher than any others types of the cancers involved in the study, suggesting that the expression of Ki67 play an important role in malignant transformation of benign lesion of breast. Detection of over expression of all these markers suggests high degree malignancy of the breast cancer.
Authors and Affiliations
Farouk Hassan
Keywords
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