Immunomodulatory effect of the saponins of Momordica Cymbalaria
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 2
Abstract
Momordica cymbalaria is a plant species that is almost ubiquitously found in different parts of the natives of tropical and subtropical Africa and Asia and Australia. Various preparations of it have been advocated in folk medicine as an abortifacient and for the treatment of diabetes mellitus. The present study investigates the Immunomodulatory potential of Methanolic extract of steroidal saponins of Momordica cymbalaria. An attempt has been made to assess the Immunomodulatory activity of purified saponin mixture (PSM) Methanolic extract of steroidal saponins of Momordica cymbalaria orally at dose of 25mg/kg was used as standard drug. The effect of steroidal saponin of Momordica cymbalaria on the immune system of rats and mice was evaluated by using different experimental models such as carbon clearance test, cyclophosphamides induced neutropenia, neutrophil adhesion test, effect of steroidal saponin of Momordica cymbalaria on serum immunoglobulins, mice lethality test, indirect haemagglutination test, hypersensitivity reaction, haemagglutination reaction and delayed hypersensitivity reaction test. Steroidal saponins of Momordica cymbalaria increased level of serum immunoglobulins. Hence it was concluded that saponins of Momordica cymbalaria increases both humoral immunity and cell mediated immunity. Steroidal saponins of Momordica cymbalaria increased both humoral immunity and cell mediated immunity.
Authors and Affiliations
Rosey Sarraf
Keywords
Related Articles
- EP ID EP195003
- DOI -
- Views 118
- Downloads 0
Review on Pott’s Disease
Pott's disease (PD) otherwise known as spinal tuberculosis is an extra-pulmonary tuberculosis that affects the spine. It is a combination of osteomyelitis and arthritis which involves multiple vertebrae. This accounts fo...
Synthesis and antimicrobial evaluation of 5-aryl-1,3,4-thiadiazole-2-ylamine derivatives
Thiadiazoles occur in nature in four isomeric forms and it contain five membered ring system with two nitrogen and one sulphur atom. In this paper we have synthesized thiadiazole derivatives and confirmed their antimicro...
Creating a database model metadata GIS history of Kazakhstan
In the article the problem of creation of information-reference subsystem of GIS on the history of Kazakhstan. To solve the problem, the author proposes new approaches reference to the map information stored in the datab...
Detection and quantification of flavonoids and phenolic acids in leaves of mussaenda glabrata (hook.f.) Hutch. by HPTLC technique
Mussaenda glabrata (Hook.f.) Hutch. ex Gamble (Rubiaceae) is traditionally used as diuretic, antiasthmatic, antimicrobial and anti- inflammatory. In this prospective study to evaluate the chromatogram detection of chloro...
Polyphenols of tea as powerhouse for healthcare because TEA is Tremendous Effective Antioxidant
Tea contains antioxidants. Tea has less caffeine than coffee. Coffee usually has two to three times the caffeine of tea. An eight-ounce cup of coffee contains around 135 mg caffeine; tea contains only 30-40 mg per cup. T...