IMPACT OF ADVERSE DRUG REACTIONS OF TOPICAL ANTI-GLAUCOMA MEDICATIONS ON THE VISION-RELATED QUALITY OF LIFE IN PRIMARY OPEN ANGLE GLAUCOMA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 56
Abstract
BACKGROUND Adverse drug reactions (ADR) to topical medications form an important cause for noncompliance in the long term management of glaucoma. This study was aimed to determine the different types of adverse drug reactions associated with glaucoma medications and their impact on the vision-related Quality of Life (vQOL) in patients with Primary Open Angle Glaucoma. MATERIALS AND METHODS Patients with Primary Open Angle Glaucoma, fulfilling the inclusion criteria were interviewed and data collected. Adverse drug reactions to topical anti-glaucoma medications were evaluated using the ‘Comparison of Ophthalmic Medications for Tolerability Questionnaire’ and quality of life related to vision was evaluated using the ‘National Eye Institute Visual Function-25 Questionnaire’. Statistical analysis was performed using the SPSS version 22. The effect of ADR on the vQOL was analysed both by a univariate and multivariate analysis using a linear regression model. RESULTS The study population included 115 patients (28% females) with mean age of 53.22 ± 11.46 years. At least one adverse drug reaction was reported in 71.2% of cases. Adverse drug reaction (ADR) was reported in nearly all patients on dorzolamide eye drops followed by timolol (74.1%), brimonidine (50%), bimatoprost (31.8%), latanoprost (39.3%) and travoprost (15%). The three most common adverse drug reactions reported were burning (60.75%), blurred vision (45.56%) and bitter taste (44.3%). The vision-related Quality scores in all subset domains were well above 50, the lowest being the general health and near activities domain. Significant association was noted between patients with ADR and low vQOL scores (P = 0.03) on multivariate analysis. CONCLUSION Adverse drug reactions to topical anti-glaucoma medications were found to have a negative impact on the vision-related quality of life in glaucoma patients, emphasising the integration of proper patient education and counselling in the long-term management.
Authors and Affiliations
Neeta Sidhan, Beena Thankappan, Georgey C. Joshy, Safna N. Fazil
Keywords
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- EP ID EP226139
- DOI 10.14260/Jemds/2017/910
- Views 93
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