Impact of Adverse Reactions on Adherence To Treatment For Mdr –Tb Under Pmdt in A Tertiary Care Teaching Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Aim: To study the adverse reactions for second line drugs in the treatment of MDR TB and its impact on adherence to the treatment Settings and Design: Department of TB & Chest diseases, Coimbatore medical college Hospital Prospective study Period of study: Jan 2014 to Dec 2014 Methods and Material: Adverse events in 109 patients of MDR-TB started on second line drugs in our tertiary care centre were observed from January2014 to December 2014. Lists of 11 adverse reactions were selected and the patients were assessed for adverse events during the 1st week of inpatient treatment and at the end of 1st month of treatment. Results:It was observed that among the 109 patients enrolled for treatment 46 patients (42%) had any one adverse drug reaction event. Among the MDR patients change of regimen was needed in only 5% of cases due to adverse event which is very low. Only 2.7% of cases discontinued treatment due to adverse reaction. This study shows that most of the adverse reactions are manageable with the standard management strategies and the default rates are very low due to adverse events. Conclusion: In resource limited settings as in India, proper development of treatment strategy, protocols to manage the adverse reactions and proper follow up as in PMDT model to treat MDR – TB leads to high percentage of continuation of treatment without interruptions.
Authors and Affiliations
Dr. Keerthivasan Sivanmani M. D(Respiratory medicine)
Keywords
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- EP ID EP595886
- DOI 10.9790/0853-1603058285
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