Impact of laparoscopic ovarian drilling on anti-mullerian hormone levels in women with clomiphene resistant polycystic ovary syndrome
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Patients with PCOS not only have raised androgen levels which leads to anovulation but may also have high AMH levels. When ovulation induction fails, androgen levels are reduced by laparoscopic ovarian drilling (LOD) thereby effecting ovulation and thus improving fertility. Studies have suggested that LOD also reduces AMH levels and the degree of its fall may forecast the success of LOD. Materials and Method: The study objective was to evaluate baseline AMH levels and its change post LOD in patients with clomiphene resistant infertility, and correlate with spontaneous rates of ovulation and pregnancy. Results: AMH levels were found to be high in clomiphene resistant PCOS. LOD was found to be safe and effective in the management of these patients and it caused statistically significant drop in AMH levels effecting spontaneous ovulations and pregnancies. Though the degree of fall did not correlate statistically with the success of the procedure, the chances of pregnancy were found to better in patients whose pre-LOD AMH levels were higher. Conclusion: AMH levels could be a useful marker in PCOS related infertility with clomiphene resistance and LOD could be a safe and effective option for management of patients with high AMH levels and fall in AMH levels may emerge as a prognostic indicator. Randomized studies with adequate sample size would bring out the utility AMH as a prognostic marker in PCOS related infertility.
Authors and Affiliations
Monica Saraswat, Tony Jose, Meenakshi Rajput, Nilopher Siddique
Keywords
Related Articles
- EP ID EP314960
- DOI 10.18231/2394-2754.2017.0066
- Views 98
- Downloads 0
Saline infusion sonography (SIS) as a diagnostic tool for various endometrial pathologies and its comparison with hysteroscopy and histopathology
Aims and Objective To assess the role of saline infusion sonography SIS in diagnosing endometrial pathologies in young peri and postmenopausal women and its comparison with hysteroscopy and histopathologyMaterials and Me...
Thyroid Disorder and Menstrual Disorders - A tertiary care hospital based cross sectional study in Silk city Kancheepuram, South India
Aim: 1. To estimate prevalence of thyroid dysfunction in reproductive women in rural area. 2. To correlate thyroid dysfunction with menstrual irregularity and nonresponding menorrhagia. Study Design: Cross sectional hosp...
Perinatal outcome in cases of borderline oligohydramnios
Introduction Oligohydramnios is associated with intrauterine growth restriction congenital anomaly neonatal and maternal morbidities The outcome in cases of borderline oligohydramnios is less clear This study was perform...
Endoscopic surgical treatment of isthmocele and it’s probale link with endometriosis. A 3-years retrospective review of combined laparoscopic and hysteroscopic surgery
The aim is to share our experience on the efficacy of combined laparoscopic and hysteroscopic surgical treatment of isthmocele and the possible link with endometriosis 28 patients with isthmocele who underwent combined l...
Role of Admission test in predicting foetal outcome in low and high risk pregnancies
Introduction: Unfortunately, risk assessment profiles used at present are insufficient. Intrapartum mortality and morbidity are not uncommon in the low risk pregnancies also. FHR and fetal acidosis can occur with the sam...