Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 6
Abstract
Stressful experiences in the early stages of life can influence brain development and maturation, and they can also increase the risk for some psychiatric disorders; however, the specific mechanisms of this effect are still poorly understood. Neural cell adhesion molecules (NCAM 120, 140, 180 kDa) are known to play an important role in normal brain development and synaptic plasticity. Therefore, we decided to investigate whether maternal separation (MS) in rats, a paradigm which models an early life stress, has any impact on the expression of NCAM proteins in the juvenile, adolescent and adult brains of both male and female rats. Specifically, we focused our efforts on the brain regions associated with dopaminergic neurotransmission. In juvenile rats, MS decreased the levels of NCAM-140 in the substantia nigra (SN) of females and NCAM-180 in the ventral tegmental area of males. During adolescence, a reduction in NCAM-180 levels in the SN and medial prefrontal cortex (mPFC) of MS females was revealed. Finally, in adulthood, a decrease in NCAM-180 expression was observed in the mPFC of MS males. The results that we obtained indicate that early life stress can affect maturation and NCAM-driven plasticity in dopaminergic brain areas at different stages of ontogenesis and with a sex-specific manner.
Authors and Affiliations
Agnieszka Chocyk, Dorota Dudys, Aleksandra Przyborowska, Marzena Maćkowiak, Krzysztof Wędzony
Keywords
Related Articles
- EP ID EP134476
- DOI -
- Views 96
- Downloads 0
Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice.
Inhibition of sodium hydrogen exchangers (NHE) has been shown to diminish seizure activity in various in vitro and in vivo models of epilepsy. In the present study, we examined the effect of amiloride, a sodium hydrogen...
Study of the interaction of glutamatergic and nitrergic signalling in conditions of the experimental airways hyperreactivity.
Background: Glutamatergic and nitrergic system participate in the control of respiratory system functions. It is only little information regarding a possible interaction of both systems in the airways hyperractivity. We...
Evaluation of the antioxidative properties of lipoxygenase inhibitors.
Background: Oxidative stress is a component of many pathological conditions including neurodegenerative diseases and inflammation. An important source of reactive oxygen species (ROS) are lipoxygenases (LOX) - enzymes re...
Mechanisms of [Ca(2+)]i elevation following P2X receptor activation in the guinea-pig small mesenteric artery myocytes.
Background: There is growing evidence suggesting involvement of L-type voltage-gated Ca(2+) channels (VGCCs) in purinergic signaling mechanisms. However, detailed interplay between VGCCs and P2X receptors in intracellula...
Drug therapy in autism: a present and future perspective.
Autism is a neurodevelopmental disorder, with a multifactorial etiology, characterized by severe abnormalities in communications, social awareness and skills, and the presence of restrictive and stereotyped patterns of b...