Impact of Physical Activity on Dyslipidemia Onset in Children and Adolescents with Type 1 Diabetes Mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2014, Vol 6, Issue 62
Abstract
The problem of treatment optimization for type 1 diabetes mellitus (DM) in children is not completely resolved so far, while recommendations concerning physical activity (PA) regimen usually do not consider the features of patients’ metabolic status. Objective of this article — to determine the features of blood lipid depending on PA level of children and adolescents with DM type 1. Materials and Methods. The study involved 173patients with DM type 1 aged 7–18 years, with disease duration from 1 to 10 years, with determination of carbohydrate metabolism indicators, blood lipids, as well as FA level using a modified adapted questionnaire. Results. It was found that children and adolescents with type 1 DM reported atherogenically directed lipid changes in terms of increased levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, low-density lipoprotein (VLDL) cholesterol and triglycerides (TG) combined with a decreased level of high-density lipoprotein (HDL) cholesterol. Identified lipid disorders were to a large degree associated with decompensation of the disease. High PA levels in children with type 1 DM is accompanied by various lipid changes depending on the state of metabolic compensation — at HbA1c level < 9 % we observed increased indicators of TG, LDL cholesterol and VLDL cholesterol, while at HbA1c level > 7.5 % — decreased HDL cholesterol. The findings show a different impact of high PA level on the state of metabolism in children with DM type 1, in particular the possibility of dyslipidemia onset and increased risk of diabetic complications.
Authors and Affiliations
O. A. Budreiko, O. V. Morozov
Keywords
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