Impaired Systemic Iron Homeostasis and Parkinson's Disease
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Introduction: Parkinson's disease is second most prevalent neurodegenerative old age disorder of basal ganglia characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability) which involves α-synuclein protein oligomers and intercellular inclusions known as "Lewy bodies" in substantia nigra and caudate nuclei that is progressive in nature. Both excess and deficiency in levels of transition metals (especially iron) can be detrimental to the central nervous system (CNS). Abnormalities in iron metabolism have been reported to produce oxidative stress which is one of the major cause in pathogenesis of Parkinson's disease. Material & Method: In the present study 79 PD patients and 80 controls of Northern Indian population were included and serum levels of Transferrin, TIBC, iron, Transferrin saturation, Ferritin were measured. Results: In this study, we observed elevated levels of Transferrin (p< 0.001), TIBC (p< 0.001) while reduction in iron (p< 0.001), Transferrin saturation (p< 0.001), Ferritin (p< 0.023) levels in serum of PD patients compared to the controls. Conclusion: These results suggest the decreased iron concentrations in the peripheral blood, indicating that the iron accumulation in the brain is not dependent of an iron overload, but probably due to impaired iron homeostasis
Authors and Affiliations
Mohit Kumar Gangania
Keywords
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