Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 1
Abstract
In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and polymers. The physicochemical properties of tablets were found within the limits. Lornoxicam is a first generation analgesic, inflammatory & antipyretic agent used in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. From developed formulations batch F1 have shown zero order drug release behavior and prolong drug release over a period of 12 h which was deemed as suitable and optimum formulation for sustained drug delivery. Results of the present study indicated the suitability of the low viscous polymer in the proportion of (drug:polymer) 1:1 in the preparation of sustained release formulation of lornoxicam.
Authors and Affiliations
Kodalkar Swapnil J| Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India, Khutale Rohan A| Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India, Salunkhe Sachin S| Department of Quality Assurance, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur, 416 013, Maharashtra, India, Mali Sachin S| Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur, 416 013, Maharashtra, India, Nadaf Sameer J3| Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur, 416 013, Maharashtra, India
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