IMPORTANCE OF PLATELET COUNT AND SEROLOGICAL MARKERS IN DIAGNOSING DENGUE INFECTION WITH SPECIAL REFERENCE TO NS1 ANTIGEN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 10
Abstract
[b]INTRODUCTION:[/b] Dengue is an acute viral infection with potential fatal complications. Specific antibody detection has been the mainstay of diagnosis which is prone for both false positive and false negative reactions. The newer parameter NS1 appears to be highly specific and reliable for diagnosis of dengue infection from the first day of fever. Platelet count is the only accessory test for diagnosis of dengue infection in the peripheral laboratories. Therefore, study was done to evaluate the importance and association of platelet counts against NS1 and IgM/IgG in dengue infections. [b]MATERIALS AND METHODS: [/b]Serum samples from clinically suspected dengue cases were tested for NS1, IgM and IgG by immunochromatography-based test. Platelet counts were obtained for all positive cases and dengue seronegative cases of fever served as controls. Test results of denguespecific parameters were compared against platelet counts. The results were subjected to statistical analysis. [b]RESULTS:[/b] Of 159 samples tested, 17 were positive for one or more dengue parameters. Of the 17, 05 were positive for NS1 only, 06 showed IgM only while 01 showed IgG only. More than one marker was detected in the remaining 05 samples. Thrombocytopenia was more consistently associated whenever NS1 was detected compared to antibody detection (P value <0.001). [b]CONCLUSIONS: I[/b]nclusion of NS1 in the diagnosis of dengue increases the detection rate significantly. In cases of fever, thrombocytopenia is more consistently found in dengue positive rather than dengue negative subjects. It correlates well when NS1 and IgM are detected simultaneously.
Authors and Affiliations
Saurabh Agarwal, Atul Rukadikar, Avinash Laghawe, Apoorva Tripathi
Keywords
Related Articles
- EP ID EP143363
- DOI 10.14260/jemds/2014/2170
- Views 84
- Downloads 0
SPINE SURGERY IN JOS, NIGERIA- AN INITIAL EXPERIENCE
BACKGROUND Spine pathologies are a common presentation to Orthopaedicians and Neurosurgeons and include degenerative diseases of the spine, spine tumours, traumatic spine injuries, spine infections and spine deformities....
THE RATE OF TUBERCULOSIS INFECTION IN HIV POSITIVE PATIENTS IN RELATION TO CD4 COUNT
[b] INTRODUCTION[/b]: Tuberculosis is the most common HIV-related opportunistic infection in India, and caring for patients with both diseases is a major public health challenge, which places an immense burden o...
DERMATOPHYTOSIS IN AND AROUND MAHABUBNAGAR
Dermatophytes are one of the most common fungal agents causing superficial skin infections. The prevalence of these infections varies from place to place and is more commonly associated with poor socioeconomic s...
RESPIRATORY PROBLEMS IN COTTON MILL WORKERS
BACKGROUND Cotton textile workers are at increased risk of respiratory symptoms such as chest tightness, chronic bronchitis and loss of pulmonary function due to inhalational exposure to cotton dust. Indore has been a hu...
QUALITY OF LIFE IN MALE AND FEMALE VITILIGO PATIENTS
[b] BACKGROUND[/b]: Vitiligo is a common, acquired discoloration of the skin, characterized by well-circumscribed ivory or chalky white macules which are flush to the skin surface1. It affects atleast 0.5-1% of...