Improve Markers of Oxidative Stress and Coagulation Parameters in Response to Atorvastatin Therapy

Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 10

Abstract

Aims: This study was undertaken to investigate the antioxidant effects of atorvastatin in treating cases of atherosclerosis associated with hyperlipidemia. Methodology: Forty local domestic rabbits were assigned to five groups (eight rabbits in each group): After two weeks acclimatization period, a group of 8 rabbits (Group I) were used as the baseline values of the study parameters. Another 8 rabbits were selected and maintained on standard chow diet (4% fat, 18% protein, 60% carbohydrate, and 4% fibers) throughout the experiment (12 weeks) and served as a normal diet control (Group II). The rest 24 rabbits were fed on an atherogenic diet for 8 weeks to induce atherogenesis. At the end of 8th week, a group of 8 atherogenic rabbits (Group III) were separated and sacrificed and served as an atherogenic-baseline group. The remaining 16 atherogenic rabbits were randomly allocated into two groups; first group received atherogenic diet only for the next four weeks and served as an atherogenic control (Group IV). The other group received atorvastatin (Group V). Results: Blood samples were collected for serum lipids, coagulation parameters and oxidation parameters. Results showed a significant improvement in the coagulation parameters and oxidation parameters in the atorvastatin treated group compared to the atherogenic control group (P= .01). Conclusion: This study illustrated the beneficial anti-oxidant effects of atorvastatin in treating atherosclerosis associated with hyperlipidemia.

Authors and Affiliations

Bassim I. Mohammad, Najah R. Hadi, Haider M. Jawad, Dina A. Jamil, Hayder A. Al-Aubaidy

Keywords

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  • EP ID EP344952
  • DOI 10.9734/BJPR/2014/10140
  • Views 121
  • Downloads 0

How To Cite

Bassim I. Mohammad, Najah R. Hadi, Haider M. Jawad, Dina A. Jamil, Hayder A. Al-Aubaidy (2014). Improve Markers of Oxidative Stress and Coagulation Parameters in Response to Atorvastatin Therapy. Journal of Pharmaceutical Research International, 4(10), 1242-1252. https://www.europub.co.uk/articles/-A-344952