IMPROVEMENT OF FAST DISINTEGRATING TABLETS USING RANITIDINE HCL
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 7
Abstract
The present study was designed towards the design and development of fast disintegrating tablets by direct compression technology using Ranitidine HCl as a model drug. Fast disintegrating tablet of Ranitidine HCl was formulated using two Superdisintegrants in different concentrations i.e. 30 mg and 35 mg. Kollidon CL and Sodium Starch Glycolate are used as Superdisintegrants. All the batches were prepared by direct compression method using the Single punch tablet compression machine using 13 mm diameter. Disintegration time and drug release were taken as the basis to optimize the immediate release tablet. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time and dissolution study. Tablets containing 30 mg Kollidon CL showed the faster disintegration time (25-30 Secs) and percent of drug release (90% in 15mins) as compared to other superdisintegrating agent.
Authors and Affiliations
Rishikesh*| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Mst Rikta Banu| Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh, Md. Zakaria Faruki| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Drishti Rani Ghosh| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Mohiuddin Ahmed Bhuiyan| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Irin Dewan| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh
Keywords
Related Articles
- EP ID EP1420
- DOI -
- Views 537
- Downloads 32
Knowledge, attitude and practice of ADR reporting among clinical residents: A rural medical college survey
Introduction: Pharmacovigilance practices have persistently suffered from under-reporting of ADRs by the clinicians. The present study was done to assess the knowledge, attitude and practices of clinical residents toward...
Transdermal drug delivery system: - a review on transdermal patch
The main advantage of Transdermal drug delivery system is to bypass the first pass metabolism, avertance of the risk and annoyance of intravenous therapy and of the varied conditions of absorption, like pH changes, gastr...
Comparison of Efficacy, Safety and Cost of Therapy with Oral Ferrous Ascorbate and Ferrous Sulphate in Patients with Iron Deficiency Anemia
Objective: To compare the efficacy and safety of oral ferrous ascorbate and ferrous sulphate in patients with iron deficiency anemiaMethods: An observational, prospective study in patients of anemia in chronic kidney dis...
In –Vitro Anthelmintic Activity of Adhatoda vasica Leaves on Indian Adult Earthworm
Herbal medicines derived from various plants are being utilized to treat various types of diseases, Adhatoda vasica is one of them.After literature survey it was observed that drug has screened for anti-tussive and anti...
Journal of Drug Discovery and Therapeutics 2 (22) 2014, 01-06
The review provides scientific and basics view on radiocarbon dating. However, his presentation, calibration and interpretation of radiocarbon ages are misleading in some cases, and important wide applications for age de...