IMS 4112 and VLP of HBV as Th1 Adjuvants for a Recombinant Protein of HIV-1
Journal Title: Journal of Vaccines and Immunology - Year 2016, Vol 2, Issue 1
Abstract
Background: Current thinking suggests that vaccination approaches against the HIV-1 should be directed to elicit a Th1 cell-mediated immunity, neutralizing antibodies and/or ADCC mediating antibody responses. Also, experimental evidences suggest that both the systemic and mucosal compartments of the immune system must be stimulated to achieve protection. In this regard, effective adjuvants are necessary. Thus, we developed the multiantigenic vaccine candidate TERAVAC that comprise the recombinant protein CR3 of HIV-1 and the surface (S) and core (C) virus like particles (VLP) of Hepatitis B virus (HBV) as adjuvant to promote a Th1 immune response. On the other side, the new Th1 adjuvant Montanide® IMS 4112 (IMS 4112), an oil-in-water micro-emulsion was developed by SEPPIC. Purpose of study: The aim of this work was to compare the adjuvant effect of IMS 4112 versus HBV VLP on the CR3(HIV-1)-specific immune response in Balb/c mice using schedules that combine nasal and/or subcutaneous inoculations.
Authors and Affiliations
Rodríguez-Alonso Ingrid, García Daymir, Brown Emma, xAscarateil Stephane Ascarateil, Iglesias Enrique
Keywords
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- EP ID EP553754
- DOI 10.17352/jvi.000018
- Views 60
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IMS 4112 and VLP of HBV as Th1 Adjuvants for a Recombinant Protein of HIV-1
Background: Current thinking suggests that vaccination approaches against the HIV-1 should be directed to elicit a Th1 cell-mediated immunity, neutralizing antibodies and/or ADCC mediating antibody responses. Also, exper...