In-silico screening of Alpha Amylase Enzyme Inhibitors from Siddha Formulation Pungampoo Chooranam by Molecular docking analysis for the management of Type II Diabetes mellitus
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 10
Abstract
Diabetes Mellitus is a major health care problem in India with prevalence of about 66.8 million and it was expected to reach 80 million by the year 2025. Type II diabetes (T2DM) accounts for the majority of all diagnosed cases of diabetes in the world with its prevalence increasing sharply in recent decade.The inhibition of alpha-amylase an enzyme involved in the digestion of carbohydrates, can significantly reduce the post-prandial increase of blood glucose and therefore can be an important strategy in the management of blood glucose level in type II diabetic and borderline patients. The main aim of the present investigation is to screen the alpha amylase enzyme inhibition potential of novel phytocomponents such as Beta Sitosterol, Glabrin, Isolonchocarpin, Kanjone, Pongol, Sterolin, Pinnatin and Quercetin present in the formulation Pungampoo Chooranam (PPC) against target protein alpha amylase receptor with PDB code 1HNY along with the standard acarbose using computational docking analysis. The results of the study indicate that the lead pinnatin has shown highest inhibition property similar to that of the standard acarbose. The second highest docking interaction possessed by beta sitosterol followed by this Isolonchocarpin, kanjone , pongol and quercetin. The leads such as glabrin and sterolin has no interaction with any of the significant amino acid residues on the target alpha amylase. Based on the results of the In-silico screening analysis it was concluded that the compound’s such as pinnatin, beta sitosterol , Isolonchocarpin, kanjone ,pongol and quercetin present in the siddha formulation PPC may possess significant anti-diabetic property by inhibition of target enzyme alpha amylase.
Authors and Affiliations
J. Nisha *1
Keywords
Related Articles
- EP ID EP570600
- DOI 10.22192/ijcrms.2017.03.10.006
- Views 124
- Downloads 0
Spontaneous esophageal perforation as a cause of upper gastrointestinal bleed – A Rarity
A 49 year old patient was referred to our emergency department with hematemesis and melena following forceful vomiting. Endoscopy revealed a Mallory Weiss tear and a large ulcer, computed tomography (CT) scan revealed a...
To compare efficacy of 10-day sequential triple therapy versus14-days sequential therapy for the eradication of H. pylori.
Background: Helicobacter pylori (H.pylori) colonization is the main main risk factor for peptic ulceration as well as for gastric adenocarcinoma and gastric MALT (mucosa-associated lymphoid tissue) lymphoma. Till date op...
Pilot Study on Efficacy Evaluation of Siddha Remedy Adathoda Cigarette in Reducing the Serum Nicotine Level for Tobacco Smoking De-Addiction
Cigarette smoking remains the leading cause of death throughout the world, further it becomes the serious factor contributing premature death in the developing countries like India. Tobacco addiction involves the interpl...
Synergestic action of siddha medicine Madhulai manapagu and Annabedhi chendooram in the treatment of iron deficiency anaemia
In India, around 49.5 percent of the women and 42 percent of children are affected by iron deficiency anaemia. Iron deficiency anaemia is due to lack of iron and vitamin C. Iron deficiency is more prevalent in women duri...
Role of Flexible Fiberoptic Bronchoscopy in Sputum Smear Negative Pulmonary Tuberculosis Patients Undergoing Treatment Under Revised National Tuberculosis Control Programme (RNTCP)
Background: India is the country with the highest burden of Tuberculosis and accounts for one fourth of the global TB burden. Sputum-negative pulmonary tuberculosis still remains a common problem, more so in immunocompro...