IN SILICO STUDIES ON DENGUE AND MEASLES VIRAL PROTEINS WITH SELECTED METHANOLIC EXTRACTS OF CORIANDER SATIVUM LEAVES CONSTITUENTS
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 12
Abstract
Coriander (Coriandrum sativum L.) has been reported to have many medicinal properties. Its plant, seeds, leaves and roots are edible, although they have very distinct flavours and uses. Coriander is also well known for its antioxidant, anti-diabetic, anti-mutagenic, antianxiety and antimicrobial activity along with analgesic and hormone balancing effect. Phytochemicals present in Coriander Sativum are also found to have and antifungal properties. In this study, the binding efficiency of 4 compounds that is present in the Coriander Sativum with two structural Dengue virus proteins and four structural measles virus proteins through Insilico methods. By molecular docking result, we found that the compound Squalene and 9, 12 octadecadienoic acid (Z,Z),2-hydroxy,1(hydroxymethy) propyl ester,2,3-dihydroxy propyl ester have highest binding affinity with the chosen viral proteins.
Authors and Affiliations
Dr. Balasubramanian Sathyamurthy
Keywords
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