IN SILICO STUDIES ON PLANT DERIVED COMPONENTS OF CISSUS QUADRANGULARIS AGAINST COX-2 ENZYME
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: Cissus quadrangularis, a perennial plant of grape family is traditionally used as an herbal medicine for treating inflammation caused by hemorrhoids, gastric ulcer and bone disorders. COX-2 is an oxidoreductase enzyme having a role in inflammatory responses. The objective of this study was to show the drug-likeness and the binding of Cissus quadrangularis derived biologically active compounds against the inflammation associated target COX-2 enzyme.Methods: The 3D structure of COX-2 enzyme protein structure was taken from PDB database (PDB ID: 6cox). The structures of plant derived compounds were retrieved from the PubChem database. The Lipinski’s properties of about 16 compounds from Cissus quadrangularis were checked and those which satisfied the Lipinski’s rule of five were subjected to docking experiments. Docking studies had been carried out through AutoDock 4.2.Results: About 6 compounds showed drug-likeness by satisfying Lipinski’s properties. The comparative molecular docking studies were done for 6 compounds which showed drug-likeness through AutoDock 4.2. The comparison reflected that flavonoid and stilbene derivatives bind in the active site region of COX-2 with good binding energy.Conclusion: The in silico studies on compounds reported from Cissus quadrangularis showed that they possess potential medicinal values with anti-inflammatory properties which form insights to develop new leads for COX-2 inhibition.Â
Authors and Affiliations
Ss Meenambiga, Rajagopal K
Keywords
Related Articles
- EP ID EP579757
- DOI -
- Views 68
- Downloads 0
CLINICAL EVALUATION OF POTENTIAL ANTI-INFLAMMATORY EFFECT OF VITAMIN D3 ADJUVANT THERAPY FOR CHRONIC ASTHMA IN IRAQI PATIENTS
Objective: This study was designed to evaluate the potential anti-inflammatory effect of vitamin D3 supplementation in Iraqi patients with chronic asthma. Methods: Forty-four candidate patients were diagnosed with asthma...
EVALUATION OF THE EXHAUSTIVE EXTRACTION YIELDS FOR TEUCRIUM POLIUM L. FROM DIFFERENT REGIONS OF THE WEST BANK - PALESTINE
Objective: Teucrium polium L. aerial parts have been used by local populations of Palestine for the treatment of various diseases as diabetes mellitus, amoeba, intestinal spasms and diarrhea for that the interest of usin...
CYTOTOXICITY OF METABOLITES PRODUCED BY ENDOPHYTIC FUNGUS CLADOSPORIUM SP. ISOLATED FROM MARINE MACROALGAE ON INÂVITRO MCFÂ7, HELA, AND DU-145 CELL LINES
Objective: To investigate the in vitro cytotoxicity effect of the crude ethyl acetate extract of Cladosporium sp. on MCF-7, HeLa, and DU-145 cell lines.Methods: In vitro cytotoxicity was evaluated by tetrazolium reductio...
EICHHORNIA MEDIATED COPPER OXIDE NANOPARTICLES: IN VITRO ANALYSIS OF ANTIMICROBIAL ACTIVITY
Objective: The present investigation determines the biological synthesis and characterization of Copper oxide nanoparticles from aqueous extract of Eichhornia crassipes and assessing its effects on antimicrobial activity...
STUDY OF ANTIOXIDANT ACTIVITY OF FORMONONETIN BY IN VITRO METHOD
Objective: Now the important field of research in phytomedicine is to search a new plant source as well as new phytoconstituents that have fewer side effects and low cost with the free radical scavenging activity. Method...