In-vitro activity of synercid and related drugs against Streptococcus oralis isolated from septicaemia and endocarditis cases
Journal Title: Sultan Qaboos University Medical Journal - Year 2000, Vol 2, Issue 1
Abstract
– The increase in resistance to gram positive organisms and seriousness of infective endocarditis, makes it necessary to look for an alternate treatment. – In-vitro activity of synercid was compared with penicillin, amoxycillin, teicoplanin, vancomycin, clindamycin and erythromycin. – Synercid showed minimum inhibitory concentrations (MIC) within the narrow range of 0.06 – 0.5 mg/l. MIC50 and mode values were both 0.25 mg/l. There was just two-fold difference between the MIC50 (0.25 mg/l) and the MIC90, (0.5 mg/l). Although the MICs of synercid for S. oralis were relatively high compared to penicillin, clindamycin, erythromycin and teicoplanin, the in-vitro bactericidal activity of synercid was much greater. Synercid MBC values were < 4 mg/l for most of the isolates, except for one of 16 mg/l and the other >64 mg/l. Killing curve was performed on six isolates of S. oralis from infective endocarditis, two from septicaemia patients and two from the oral flora of normal individuals. – Synercid showed superior bactericidal activity when compared to penicillin and vancomycin against all ten isolates of S. oralis tested. Synercid was bactericidal (99.9% kill) against all ten isolates of S. oralis within six hours of contact.
Authors and Affiliations
Rafay A M| Department of Microbiology, College of Medicine, Sultan Qaboos University, P.O.Box: 35, Postal Code: 123, Muscat, Sultanate of Oman
Keywords
Related Articles
- EP ID EP13602
- DOI -
- Views 388
- Downloads 18
Measles on the Rise: The importance of vaccination
Measles was thought to be almost eradi- cated, however, recent reports from around the world are proving otherwise. In 2018, the World Health Organization (WHO) received reports of approximately 229,000 cases of measle...
Molecular Imaging Bridging Imaging and Biology
Oman Urological Society Conference 2019
Objectives: First lines of evidence have shown that metformin inhibits cancer cell growth and prevents cancer occurrence in patients with type 2 diabetes. Tis study aimed to investigate the hypothesised inhibitory effect...
Heerfordt’s Syndrome An interesting and under-recognised manifestation of sarcoidosis
Tocotrienol-Rich Fraction from Palm Oil Prevents Oxidative Damage in Diabetic Rats
Objectives: Tis study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage...