IN VITRO ANTHELMINTIC ACTIVITY OF SECURIDACA LONGEPEDUNCULATA FRESEN. (POLYGALACEAE) AQUEOUS ROOT BARK EXTRACT AGAINST ASCARIDIA GALLI AND RAILLIETINA ECHINOBOTHRIDA ADULT WORMS FROM GUINEAFOWL (NUMIDA MELEAGRIS)
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
Securidaca longepedunculata Fresen. (Polygalaceae) is commonly used in Burkina Faso by traditional herbalists and pastoralists to control gastrointestinal parasites. The aim of this study was to screen the aqueous extract of Securidaca longepedunculata for its anthelmintic properties against tapeworms (Raillietina echinobothrida) and roundworms (Ascardia galli). Various concentrations of the plant extract was tested in this bioassay and different parameters such as determination of time of paralysis and time of death of the worms were recorded. Levamisole and Trenamide were used as reference standard against resp. tapeworms (Raillietina echinobothrida) and roundworms (Ascardia galli) and NaCl solution (0.9%) as zero control. All the extracts exhibited significant anthelmintic activity at highest concentration of 50 mg/mL. For Ascaridia galli, efficacy against adult worms in 12.5 and 25 mg/mL of aqueous extract of Securidaca longepedunculata at 24 h was 29% (p<0.05) and 61% (p<0.05) and at 36h was 39% (p>0.05) and 100% (p < 0.05) respectively, when compared to the control group. No Ascaridia galli survived after 24 h in 50 and 100 mg/mL (p<0.001) of aqueous extract of Securidaca longepedunculata. The efficacy against R. echinobothrida, at 0.625, 1.25 and 2.5 mg/mL of aqueous extract of Securidaca longepedunculata at 2 h was 0% (p>0.05), 32% (p< 0.05) and 48% (p< 0.05). After 4 h, it was 12% (p< 0.05), 72% (p< 0.05) and 88% (p< 0.05), respectively, when compared to the control group. No Raillietina echinobothrida survived for 2 h in 5 mg/mL of aqueous extract of Securidaca longepedunculata (p< 0.01).
Authors and Affiliations
Dr. Almamy Konaté
Keywords
Related Articles
- EP ID EP614242
- DOI -
- Views 232
- Downloads 0
OMEGA-3 POLYUNSATURATED FATTY ACIDS, LIPID PROFILE, INSULIN RESISTANCE AND DIABETIC CARDIAC AUTONOMIC NEUROPATHY
Background: The significance of cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM) has been not fully appreciated and there is no unified treatment algorithm. Aim: The aim of study was to...
EFFECT OF AGE AND DURATION OF INFERTILITY ON LEVELS OF INTERLEUKIN-18 AND CORRELATION TO PREGNANCY RATE FOR WOMEN UNDERGOING ICSI PROGRAM
Background: Interleukin-18 (IL-18) is a cytokine which belongs to the interleukin-1 (IL-1) superfamily. Although initially thought to be synthesized mainly by the macrophage and adiposity, now it has been found that IL-1...
NODDING SYNDROME IN NORTHERN UGANDA; TREATMENT AND REHABILITATION OUTCOMES: A LONGITUDINAL STUDY DESIGN
Background: Nodding Syndrome (NS) is an emerging neurological disorder in East Africa that affects children that are subject to civil disruption, internal displacement, food insecurity, malnutrition and nematode infectio...
IMPROVEMENT OF GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF BRASSICA RAPA SUBSP. RAPA ROOTS AND ZINGIBER OFFICINALE RHIZOMES
Background. Brassica rapa subsp. rapa (Brassicaceae family) and Zingiber officinale (Zingiberaceae family) are two plants cultivated in Bangladesh, respectively, for consumption as vegetable and as spice. A number of Bra...
HYDROMETHANOLIC LEAF EXTRACT OF OCIMUM GRATISSIMUM IMPROVES VISUO-SPATIAL LEARNING AND MEMORY IN MICE
This study evaluated the effect of hydromethanolic leaf extract of Ocimum gratissimum (HMOG) on visuo-spatial learning and memory in mice. Mice were randomly assigned into four groups of 6 mice each. Group 1 received dis...