IN VITRO ANTHELMINTIC ACTIVITY OF SECURIDACA LONGEPEDUNCULATA FRESEN. (POLYGALACEAE) AQUEOUS ROOT BARK EXTRACT AGAINST ASCARIDIA GALLI AND RAILLIETINA ECHINOBOTHRIDA ADULT WORMS FROM GUINEAFOWL (NUMIDA MELEAGRIS)
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
Securidaca longepedunculata Fresen. (Polygalaceae) is commonly used in Burkina Faso by traditional herbalists and pastoralists to control gastrointestinal parasites. The aim of this study was to screen the aqueous extract of Securidaca longepedunculata for its anthelmintic properties against tapeworms (Raillietina echinobothrida) and roundworms (Ascardia galli). Various concentrations of the plant extract was tested in this bioassay and different parameters such as determination of time of paralysis and time of death of the worms were recorded. Levamisole and Trenamide were used as reference standard against resp. tapeworms (Raillietina echinobothrida) and roundworms (Ascardia galli) and NaCl solution (0.9%) as zero control. All the extracts exhibited significant anthelmintic activity at highest concentration of 50 mg/mL. For Ascaridia galli, efficacy against adult worms in 12.5 and 25 mg/mL of aqueous extract of Securidaca longepedunculata at 24 h was 29% (p<0.05) and 61% (p<0.05) and at 36h was 39% (p>0.05) and 100% (p < 0.05) respectively, when compared to the control group. No Ascaridia galli survived after 24 h in 50 and 100 mg/mL (p<0.001) of aqueous extract of Securidaca longepedunculata. The efficacy against R. echinobothrida, at 0.625, 1.25 and 2.5 mg/mL of aqueous extract of Securidaca longepedunculata at 2 h was 0% (p>0.05), 32% (p< 0.05) and 48% (p< 0.05). After 4 h, it was 12% (p< 0.05), 72% (p< 0.05) and 88% (p< 0.05), respectively, when compared to the control group. No Raillietina echinobothrida survived for 2 h in 5 mg/mL of aqueous extract of Securidaca longepedunculata (p< 0.01).
Authors and Affiliations
Dr. Almamy Konaté
Keywords
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