IN VITRO ANTHELMINTIC ACTIVITY OF SECURIDACA LONGEPEDUNCULATA FRESEN. (POLYGALACEAE) AQUEOUS ROOT BARK EXTRACT AGAINST ASCARIDIA GALLI AND RAILLIETINA ECHINOBOTHRIDA ADULT WORMS FROM GUINEAFOWL (NUMIDA MELEAGRIS)

Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 1

Abstract

Securidaca longepedunculata Fresen. (Polygalaceae) is commonly used in Burkina Faso by traditional herbalists and pastoralists to control gastrointestinal parasites. The aim of this study was to screen the aqueous extract of Securidaca longepedunculata for its anthelmintic properties against tapeworms (Raillietina echinobothrida) and roundworms (Ascardia galli). Various concentrations of the plant extract was tested in this bioassay and different parameters such as determination of time of paralysis and time of death of the worms were recorded. Levamisole and Trenamide were used as reference standard against resp. tapeworms (Raillietina echinobothrida) and roundworms (Ascardia galli) and NaCl solution (0.9%) as zero control. All the extracts exhibited significant anthelmintic activity at highest concentration of 50 mg/mL. For Ascaridia galli, efficacy against adult worms in 12.5 and 25 mg/mL of aqueous extract of Securidaca longepedunculata at 24 h was 29% (p<0.05) and 61% (p<0.05) and at 36h was 39% (p>0.05) and 100% (p < 0.05) respectively, when compared to the control group. No Ascaridia galli survived after 24 h in 50 and 100 mg/mL (p<0.001) of aqueous extract of Securidaca longepedunculata. The efficacy against R. echinobothrida, at 0.625, 1.25 and 2.5 mg/mL of aqueous extract of Securidaca longepedunculata at 2 h was 0% (p>0.05), 32% (p< 0.05) and 48% (p< 0.05). After 4 h, it was 12% (p< 0.05), 72% (p< 0.05) and 88% (p< 0.05), respectively, when compared to the control group. No Raillietina echinobothrida survived for 2 h in 5 mg/mL of aqueous extract of Securidaca longepedunculata (p< 0.01).

Authors and Affiliations

Dr. Almamy Konaté

Keywords

Related Articles

AYURVEDIC APPROACH TO TREAT SWINE FLU

Ayurvedic medicine is one of the world's oldest holistic (“wholebody”) healing systems. It was developed more than 3,000 years ago in India. Ayurveda, the traditional 'science of life', has a remedy for diseases when eve...

SYNTHESIS OF N-4-METHOXYBENZOYL-N'-PHENYLUREA COMPOUND AND ACTIVITY TEST OF ANTICANCER AGAINST HeLa CELL LINE

Research in the search for cancer drug compounds continues to be developed, considering that specific anticancer compound has not been obtained. Some of the urea derivative compounds are also being developed in the searc...

IMPROVEMENT BY THE AQUEOUS EXTRACT OF THE LEAVES OF DESMODIUM VELUTINUM WILL DC (FABACEAE) OF BIOLOGICAL PARAMETERS ALTERED BY ETHANOL 30 % IN RATS

Most epidemiological data show that regular alcohol consumption is related to an increase the occurrence of cardiovascular diseases, dysfunction of noble organs and changes in biochemical and hematological parameters. Th...

ACUTE AND SUB-ACUTE TOXICITY EVALUATION OF DISULPHIDE DERIVATIVE OF DIHYDROARTEMISININ

Dihydroartemisinin (DHA), the active metabolite of artemisinins, possesses anticancer activity but its usefulness may be limited by its short half-life. Recently, a persulphide (or disulphide) derivative of DHA (sDHA) ha...

FURTHER STUDIES OF DEATH AND PROGRESSIVE ELIMINATION OF INTRACELLULAR TOXOPLASMA GONDII IN PRESENCE OF HYDROXYUREA

Toxoplasma gondii tachyzoite infects and resides within a special parasitophorous vacuole in eukaryotic cells. Viable parasites manipulate the vacuole allowing the uptake of nutrients from the host cell while avoid paras...

Download PDF file
  • EP ID EP614242
  • DOI -
  • Views 233
  • Downloads 0

How To Cite

Dr. Almamy Konaté (2017). IN VITRO ANTHELMINTIC ACTIVITY OF SECURIDACA LONGEPEDUNCULATA FRESEN. (POLYGALACEAE) AQUEOUS ROOT BARK EXTRACT AGAINST ASCARIDIA GALLI AND RAILLIETINA ECHINOBOTHRIDA ADULT WORMS FROM GUINEAFOWL (NUMIDA MELEAGRIS). World Journal of Pharmaceutical Research, 6(1), 31-40. https://www.europub.co.uk/articles/-A-614242