IN VITRO ANTI-INFLAMMATORY ACTIVITY OF SYRINGIC ACID
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 2
Abstract
Objective: The present study was carried out to investigate the in vitro anti-inflammatory activity of syringic acid (SA). Methods: SA was tested for it's in vitro anti-inflammatory activity at different concentrations in protein denaturation, proteinase inhibition and human red blood cell (HRBC) membrane stabilization assay. The reference drugs used were aspirin and diclofenac sodium. Results: SA showed concentration-dependent inhibition of protein denaturation and proteinase activity with a half-maximal inhibitory concentration (IC50) value of 49.38±0.56 µg/ml and 53.73±0.27 µg/ml respectively. Heat-induced haemolysis was inhibited by SA with an IC50 value of 57.13±0.24 µg/ml. SA also inhibited the hypotonicity-induced haemolysis (IC50 value of 53.87±0.72 µg/ml). Conclusion: From the present study, we can conclude that SA possesses appreciable anti-inflammatory effect against denaturation of proteins, proteinase activity, and human red blood membrane stabilization assays. Further studies are required for determining the possible mechanisms behind its anti-inflammatory action.
Authors and Affiliations
Shilpee Chanda, Archana R. Juvekar
Keywords
Related Articles
- EP ID EP566039
- DOI 10.22159/ijpps.2019v11i2.30387
- Views 93
- Downloads 0
NEPHROPROTECTIVE, NEPHROCURATIVE ACTIVITY OF MIMOSA PUDICA ROOT AGAINST GENTAMICIN INDUCED NEPHROTOXICITY
Objective: To study nephroprotective effect of ethanolic extract of Mimosa pudica root against Gentamicin induced nephrotoxicity in rats. Methods: After the treatment scheduled period of 21 days, the extent of nephrotox...
ENHANCED APOPTOSIS IN MCF-7 HUMAN BREAST CANCER CELLS BY BIOGENIC GOLD NANOPARTICLES SYNTHESIZED FROM ARGEMONE MEXICANA LEAF EXTRACT
Objective: To assess the in vitro anticancer activity of A. mexicana mediated gold nanoparticles on MCF-7 breast cancer cells.Methods: The present study reveals the synthesis and characterization of gold nanoparticles fr...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF BALOFLOXACIN IN BULK AND TABLET DOSAGE FORM
Objective: The objective of the method was to develop a simple, rapid, efficient, cost effective and reproducible, stability indicating (RP-HPLC) Reverse Phase High Performance Liquid Chromatography method for the estima...
EVALUATION OF SUPPLEMENTING HERBAL PRODUCT TO SOWS FOR IMPROVING LITTER WEIGHT AND REDUCING PIGLET MORTALITY
Objective: To examine the impact of the herbal product in improving litter weight, reducing piglet mortality and increasing milk production in sows.Methods: 20 sows which were in their late gestation period were randomly...
EFFECT OF NON-VOLATILE SOLVENT AND EXCIPIENT RATIO ON FLOW AND CONSOLIDATION PROPERTIES OF POWDER BLEND FOR LIQUISOLID COMPACTS
Objective: To study the effect of non-volatile solvent and excipient ratio on flow and consolidation properties of powder blend for liquisolid compacts.Methods: The effect of non-volatile solvent and excipient ratio on f...