In vitro Antihistaminic Activity of hydro-alcoholic extract of Sida acuta Burm
Journal Title: International Journal of Pharmacology and Clinical Research (IJPCR) - Year 2018, Vol 2, Issue 1
Abstract
Sida acuta is a shrub indigenous to pantropical areas, widely distributed in regions and found in pastures, waste lands, cultivated lands, roadsides, lawns and planted forests. Sida acuta is ethanomedically used as treatment of diuretic, asthma, fever, headache, cough, cold, ulcer, anthelmintic, snake bite, urinary disease, female disorders, sedative, eczema, kidney stone, elephantiasis, testicular swelling, poultice for dandruff, rheumatic affections, facial paralysis, pulmonary tuberculosis and gonorrheae. The phytochemical screening revealed the presence of tannin, saponin, flavonoid, terpenoids, cardio glycoside, vitamin composition and minerals composition was calcium, magnesium, zinc, steroids, phenolic compounds, sesquiterpene, alkaloid cryptolepine, quindoline, quindolinone and fixed oil. The hydro-alcoholic extract of Sida acuta was for its antihistaminic studies by using guinea pig ileum and tracheae. The percentage inhibition of hydro-alcoholic extract of Sida acuta (100µg/ml) on histamine induced contraction showed 60.6% in comparision with chlorpheniramine (1µg/ml) 69.69%. The present research study draws the conclusion that hydro-alcoholic extract of Sida acuta showed moderate antihistaminic effect which may be due the combined nature phytoconstituents.
Authors and Affiliations
Krishnaveni A
Keywords
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