IN VITRO ANTIOXIDANT ACTIVITY OF <em>PROSOPIS CINERARIA</em> LEAVES AGAINST H<sub>2</sub>O<sub>2</sub> INDUCED OXIDATIVE STRESS IN GOAT LIVER SLICES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: To evaluate the antioxidant status of goat liver slices treated with standard oxidant H2O2in the presence and the absence of methanolic leaf extract of Prosopis cineraria.Methods: Precision-cut goat liver slices were challenged with oxidant H2O2 with or without the methanolic leaf extract of Prosopis cineraria. The activity of enzymic antioxidants and the levels of non-enzymic antioxidants were analysed in the homogenate of liver slices.Results: The levels of antioxidants were drastically decreased in oxidant treated group compared to untreated control, whereas there was a significant increase in the antioxidants levels in the methanolic leaf extract treated group.Conclusion: The organ slices represent the multicellular, structural and functional features of in vivo tissues and therefore represent as a good in vitro model. The present study revealed that leaf extract improved the antioxidant status of the goat liver slices and also protected against oxidative damage.Â
Authors and Affiliations
Dharani Bangaruswamy, Sivaprabha Jambunathan, Palghat Raghunathan Padma, Sumathi Sundaravadivelu
Keywords
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