In vitro cytotoxic activity of ethanolic extract of Triumfetta rhomboidea against different cancer cell lines
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 1
Abstract
Triumfetta rhomboidea (TR) is being used in traditional medicine for a variety of ailments. It is widely distributed in tropical and subtropical part of India up to an elevation of 1,200 m in the Himalayas. Triumfetta rhomboidea is used for tumor, leprosy, gonorrhea, intestinal ulcer, dysentery and various other ailments. The aim of the work is to explore phytochemical constituents present in leaves extract and to evaluate the cytotoxic activity of the plant. The phytochemical investigation of the ethanolic extract of Triumfetta rhomboidea revealed the presence of carbohydrates, glycosides, tannins, flavonoids, steroids, saponins and terpenoids. To substantiate the traditional claim of TR for its cytotoxic activity, extract was tested on different cell lines (In vitro). The leaves extract from Triumfetta rhomboidea was subjected for cytotoxic activity against HT-29 (Human, colorectal cancer cell line), HeLa (Human, Epithelial cervical cancer) and C2 C12 (Mouth muscle cell line) cell lines by Microculture Tetrazolium (MTT) assay method. The extract exhibited moderate cytotoxic properties towards cancerous cell lines HT-29 and HeLa models. Where as against C2C12, test extract failed to exhibit cytotoxicity even at higher test concentrations. Cytotoxicity tests indicated that the extract has moderate cytotoxic effect.
Authors and Affiliations
S. Hemalatha S. Hemalatha
Keywords
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