In Vitro Lethal Effect of Ellagitannins of the Fruit Rind of Punica Granatum and Stem and Root Alkaloids on The Miracidia and Cercariae of Schistosoma Mansoni
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Ellagitannins of fruit rind and alkaloids of the stem and root of Punica granatum (P. granatum) were investigated for their in vitro lethal effect on miracidia, and cercariae of Schistosoma mansoni (S. mansoni). All the three investigated constituents were lethal to both Schistosome larvae at concentrations ranging between 0.39-50 ppm. At 0.39 ppm of the tested active constituents, the killing time of 50% of Schistosoma larvae ranged between 30.0 to 135 min, and 43 to 380 min, for miracidia and cercariae, respectively. While stem alkaloids were generally more active against cercariae, root alkaloids were more effective against miracidia. At 3.125 ppm, the LT100 for cercariae and miracidia were respectively, 50 and 120 min for the stem alkaloids, and 300 and 30 min for root alkaloids. Ellagitannins were also more effective against miracidia than cercariae. At a concentration of 6.25 ppm, ellagitannins killed 50% of the cercariae and miracidia after 42 and 3 min, respectively. Ellagitannins could be prepared cheaply from pomegranate fruit rind which is produced in large amounts during the commercial production of pomegranate juice. Therefore, ellagitannins could be used as an affordable method for the control schistosomiasis.
Authors and Affiliations
Khalid H. Abu Zeid, Mohamed F. El-Badawy, Saad A. Gumaa, 4, Ahmed Ismael, Mohamed M. Shohayeb
Keywords
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