In Vitro Susceptibility of Escherichia coli and Enterococcus faecalis Isolates from Patients with Urinary Tract Infections to Fosfomycin in North India: A Retrospective Study in a Tertiary Care Center
Journal Title: MGM JOURNAL OF MEDICAL SCIENCES - Year 2018, Vol 5, Issue 3
Abstract
There has been a rapid rise in multidrug-resistant uropathogenic organisms. A retrospective study was carried out in our Institution, which is a Tertiary Care Center in North India, to find out susceptibility of Escherichia coli (E. coli) and Enterococcus faecalis (E. faecalis) isolates to an older generation antibiotic fosfomycin. A total of 3270 isolates from urinary samples were tested. 1701 (52.02%) were E. coli and 500 (15.29%) Enterococcus faecalis isolates. 704 (41.39%) of E. coli were found to be extended spectrum β-lactamase (ESBL) producers and 183 (10.76%) metallo β-lactamase (MBL) producers. Out of 500 E. faecalis isolates, 247 (47.4%) were high-level aminoglycoside resistant (HLAR) and 5 (1%) vancomycin-resistant enterococci (VRE). On testing sensitivity to fosfomycin, 94.89% ESBL producing E. coli, 89.16% MBL producing E. coli, 97.17% HLAR and 80% VRE were found susceptible. Overall only 1.09% of E. Coli and 1.33% of Enterococcus faecalis isolates were fosfomycin resistant. From this study, we conclude that fosfomycin may be considered as a useful oral antibiotic for the treatment of urinary tract infections with drug-resistant E. coli and/or E. faecalis.
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Hybrid Laparoscopic and Video-assisted Thoracoscopic Surgery Repair of Recurrent Traumatic Diaphragmatic Hernia: A Case Report and Literature Review
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Effect of Sensitization to Increase Awareness and Willingness for Eye Donation among Educated Professionals from a Non-medical Background
Aim: To study the effect of sensitization on awareness and willingness for eye donation among educated professionals from a non-medical background.