In vivo Antimalarial Activity of Capparis tomentosa Lam. in Mice Infected with Plasmodium berghei

Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2019, Vol 5, Issue 2

Abstract

The present study was aimed to assess the antiplasmodial properties of crude extracts of Capparis tomentosa Lam. The plant materials were collected from their natural habitat and extracted using 80% methanol and non-polar solvents. A Plasmodium berghei, which is a parasite that infects mice, was kept up at the Aklilu Lemma Institute of Pathobiology laboratory and it was injected into experimental mice. The mice were given 1x107 parasites intraperitoneally for initial infection. The extracts were given through oral gavage daily for four days, since the day when infection was commenced. The negative control groups were given the equivalent amount of solvent (vehicle) used to suspend each dose of the extract. For the positive control groups, Chloroquine was given orally as a standard drug. Data obtained from the experiment was analyzed using one way ANOVA. The results indicated that the plant extracts exhibited significant antimalarial activities. Extracts from the plant extract exhibited significant antimalarial activities and prevented body weight loss (P<0.05) but did not prevent PCV reduction in dose dependent manner and mean survival time was not prolonged. The hydro-alcoholic extract of C. tomentosa was found to be the most active with a suppression of 78.2% at the dose of 1000 mg/kg. Therefore, the results indicated the potential use of the claimed medicinal plant for the treatment of malaria in primary health care.

Authors and Affiliations

Sibhatu Gebrehiwot, Murtse Giday, Berhanu Erko, Yalemtsehay Mekonnen

Keywords

Related Articles

Plant kingdom Nutraceuticals for diabetes

Recent years witnessed an upsurge in the use of nutraceuticals, nutritionals and naturals in therapeutics at global level. Conventional treatment options available as synthetic drugs does not meet properly the therapeuti...

Reduction of Bacterial growth in Urine after an Ayurvedic treatment protocol: A case report

Urinary tract infection (UTI) is the most common bacterial infection treated in general medical practice. It is more common in females than males except in first year of life and in men over 60. Main aetiology is the bac...

Uttar Basti- A critical review

In Ayurvedic Gynecology Sthanik Chikitsa (Local therapies) are the specialized treatment procedures. These procedures basically deal with the disorders of Tryavarta Yoni (Three coverings of Vagina). Vitiation of Vata is...

Comparative physico-chemical validation between Arsenic-based Indian traditional drugs Haratal Bhasma and Rasamanikya

Background: Arsenic containing drugs Rasamanikya (RM) and Haratal Bhasma (HB) are used in Ayurveda for the treatment of several ailments. They are prepared from raw Haratal (RH) by the distinct Ayurvedic procedure. Hence...

Ayurvedic approach to Osgood Schlatter disease: A case report

Osgood Schlatter disease (OSD) is an inflammatory injury of the growth plate on the tibia just below the level of the knee at the tibial tubercle. The tibial tubercle is the bony attachment of the quadriceps (front thigh...

Download PDF file
  • EP ID EP607847
  • DOI -
  • Views 91
  • Downloads 0

How To Cite

Sibhatu Gebrehiwot, Murtse Giday, Berhanu Erko, Yalemtsehay Mekonnen (2019). In vivo Antimalarial Activity of Capparis tomentosa Lam. in Mice Infected with Plasmodium berghei. Journal of Ayurvedic and Herbal Medicine, 5(2), 44-48. https://www.europub.co.uk/articles/-A-607847