In vivo Antithrombotic Activity of Ethanolic Extract from Ocimum basilicum L.
Journal Title: Annual Research & Review in Biology - Year 2017, Vol 20, Issue 5
Abstract
Aims: In this study, the antithrombotic activity of ethanolic extract from Ocimum basilicum L. was investigated on mice. The active component of Ocimum basilicum L. was extracted in 40% ethanol by Soxhlet extractor. Place and Duration of Study: Department of Pharmacology, Faculty of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, China, between February, 2009 and July, 2009. Methodology: The crude extract was gavaged to mice in different concentration (100mg/ml, 200 mg/ml, and 400 mg/ml), for 21 days, Salvia Tablets were used as a positive control. On the final day, 50 mg/kg carrageenan was injected intraperitoneally to induce blood coagulation. Fibrin degradation products (FDPs) were assayed. Results: Results showed that the content of mice FDPs significantly（P<0. 05）increased in the 200 mg/ml dose group and 400mg/ml dose group compared to the control group. This was dose-dependent. Conclusion: The ethanolic extract of Ocimum basilicum L can activate the fibrinolytic system so as to stimulate Plasminogen enzyme into fibrinolytic enzyme to show antithrombotic activity.
Authors and Affiliations
Abudukadeer Kuerban, Yaaser Q. Almulaiky, Ryan A. Sheikh, Saeed Ahmed Alzahrani, Hasan A. Al-Talhi, Md. Nasrullah, Said Salama Moselhy, Khalid Omar Abulnaja
Keywords
Related Articles
- EP ID EP315013
- DOI 10.9734/ARRB/2017/38047
- Views 95
- Downloads 0
Public Health Risk of Abattoir Operation in Zango Abattoir Zaria, Kaduna State Nigeria
Background: Abattoir activities are known to pollute the environment, posing significant public health concerns. These activities can predispose abattoir workers and individuals living close to abattoirs to certain infec...
The Impact of Durable and Regular Training in Hand-to-hand Fighting Section on Aggregative Platelet Activity of Persons at the First Mature Age
Platelets, as one of the main elements of a body’s homeostasis, support it on the whole and especially blood system. Through the modulation of their activity in response to different impacts they can influence the microc...
Research on the Ecology of Water Mites (Acari: Hydracarina) in North-East of Algeria (Wetland Complex of El-Kala National Park)
An analysis of eight physical and chemical parameters was realized to determine the influence of species on the biodiversity of water mites. A total of 292 water mites belonging to 9 species were collected from the two l...
Antibacterial Evaluation of Aqueous and Ethanol Extracts of Ocimum gratissimum and Carica papaya
Aims: This study was carried out to evaluate the antibacterial activity of aqueous and ethanol leaf extracts of Ocimum gratissimum and Carica papaya against selected clinical isolates of Gram-negative bacteria and to als...
The Relationship between Homocysteine and Fragility Fractures - A Systematic Review
It is known that increased levels of homocysteine in plasma have been associated with various diseases. Current studies show that homocysteine is a new risk factor for the development of osteoporosis. Fragility fractures...