IN-VIVO PHARMACOKINETIC STUDIES OF SOLID DISPERSIONS OF CELECOXIB
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
Dissolution rate and dissolution efficiency of poorly soluble non-steroidal anti inflammatory drugs (NSAIDs) could be markedly enhanced by solid dispersion technology. Solid dispersions of celecoxib (C) are subjected to in vivo pharmacokinetic evaluation to evaluate whether these systems improve oral bio availability of the celecoxib. All the pharmacokinetic parameters of absorption, namely Ka, Cmax, Tmax, percent absorbed to various times and AUC indicated rapid absorption and higher bioavailability of celecoxib when administered as its solid dispersions. The absorption rate constant (Ka) was found to be 3.5526hr-1 in the case of celecoxib-Croscarmellose-Poly venyl pyrrolidine (C-CC-PVP) solid dispersion. Where as in the case of celecoxib Ka was only 0.412 hr-1. An increase of 8.6 fold in Ka was observed with celecoxib-CC-PVP solid dispersion. AUC (extent of absorption) was also much higher in the case of celecoxib -CC-PVP solid dispersion when compared to celecoxib. [AUC]0-12h was increased from 91.54 ng-hr/ml for celecoxib to 587.13 nghr/ml for celecoxib-CC-PVP solid dispersion . Both Ka and AUC were markedly increased by CCPVP solid dispersion . Thus, the results of pharmacokinetic studies indicated rapid and higher oral absorption of celecoxib when administered as CC-PVP solid dispersion.
Authors and Affiliations
Prof. Nagabhushanam
Keywords
Related Articles
- EP ID EP124127
- DOI -
- Views 147
- Downloads 0
OPERATIONAL INDICATORS OF DOTS THERAPY AT MNR MEDICAL COLLEGE & HOSPITAL, SANGAREDDY
Background: The Government of India, WHO and World Bank together reviewed the NTP in the year 1992. The revised strategy was introduced in the country as a Pilot Project since 1993 in a phased manner as Pilot Phase I, Pi...
CHITOSAN: A BIOCOMPATIBLE POLYMER FOR PHARMACEUTICAL APPLICATIONS IN VARIOUS DOSAGE FORMS
Chitosan is a weak cationic polysaccharide composed essentially of β(1→4) linked glucose amine units together with some acetyl glucose amine units. It is obtained by extensive deacetylation of chitin, a polysaccharide co...
FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN
The purpose of this research work was to establish mucoadhesive buccal tablets of Baclofen in the forms of monolayered tablets. The tablets were prepared using Sodium methyl cellulose (NaMC ), sodium alginate and Methoce...
PHARMACOEPIDEMIOLOGY: A COMPLEMENT TO THERAPEUTIC TRIALS
Pharmacoepidemiology as a discipline goes beyond epidemiologic studies of drug-related topics. Some topics receiving much attention in Pharmacoepidemiology get little in traditional epidemiology, where as others included...
SPECTROPHOTOMETRIC ESTIMATION OF SPARFLOXACIN IN BULK<br /> AND PHARHARMACEUTICAL DOSAGE FORMS
Two simple and sensitive visible Spectrophotometric methods [I and II] have been developed for the quantitative estimation of Sparfloxacin in bulk and Pharmaceutical dosage forms. Method-I is based on ion-pair complex fo...