Increased Resistin Levels in Intra-abdominal Sepsis Correlation with proinflammatory cytokines and Acute Physiology and Chronic Health Evaluation (APACHE) II scores
Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 4
Abstract
Objectives: Resistin, a hormone secreted from adipocytes and considered to be a likely cause of insulin resistance, has recently been accepted as a proinflammatory cytokine. Tis study aimed to determine the correlation between resistin levels in patients with intra-abdominal sepsis and mortality. Methods: Of 45 patients with intraabdominal sepsis, a total of 35 adult patients were included in the study. Tis study was undertaken from December 2011 to December 2012 and included patients who had no history of diabetes mellitus and who were admitted to the general surgery intensive care units of Gazi University and Bülent Ecevit University School of Medicine, Turkey. Evaluations were performed on 12 patients with sepsis, 10 patients with severe sepsis, 13 patients with septic shock and 15 healthy controls. Te patients’ plasma resistin, interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), procalcitonin, lactate and glucose levels and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were studied daily for the frst fve days after admission. A correlation analysis of serum resistin levels with cytokine levels and APACHE II scores was performed. Results: Serum resistin levels in patients with sepsis were signifcantly higher than in the healthy controls (P <0.001). A signifcant correlation was found between serum resistin levels and APACHE II scores, serum IL-6, IL-1β, TNF-α, procalcitonin, lactate and glucose levels. Furthermore, a signifcant correlation was found between serum resistin levels and all-cause mortality (P = 0.02). Conclusion: Te levels of resistin were signifcantly positively correlated with the severity of disease and were a possible mediator of a prolonged inflammatory state in patients with intra-abdominal sepsis.
Authors and Affiliations
Tonguç U. Yilmaz| Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey, Mustafa Kerem| Departments of General Surgery, Gazi University, Ankara, Turkey, Canan Y. Demirtaş| Departments of Medical Biochemistry, Gazi University, Ankara, Turkey, Özge Pasaoǧlu| Departments of Medical Biochemistry, Gazi University, Ankara, Turkey, Öge Taşcilar| Departments of General Surgery, Gazi University, Ankara, Turkey, Ömer Şakrak| Departments of Medical Biochemistry, Gazi University, Ankara, Turkey, Kürşat Dikmen| Departments of General Surgery, Gazi University, Ankara, Turkey, Tarkan Karahan| Departments of Gastroenterology, Gazi University, Ankara, Turkey
Keywords
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