Increased Serum Elabela Level Related to NT-proBNP in Patients with Heart Failure
Journal Title: E Journal of Cardiovascular Medicine - Year 2020, Vol 8, Issue 1
Abstract
Objectives: Apelin levels have been shown to be increased in heart failure with reduced ejection fraction (HFrEF). However, the Elabela level in this patient group and its relationship with laboratory parameters are not clearly known. The aim of this study was to investigate the change in serum Elabela level in patients with HFrEF and its relationship with other clinical, laboratory and echocardiographic parameters. Materials and Methods: The study included 89 patients with HFrEF and 73 age-sex-matched healthy controls. Serum Elabela level was measured in addition to routine anamnesis, physical examination, laboratory and echocardiography examinations. Results: In patients with HFrEF; aspartate aminotransferase (AST), alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP), N-terminal pro B-type natriuretic peptide (NT-proBNP), and Elabela levels were significantly higher than those in healthy controls. Serum Elabela level was found to be positively correlated with blood urea nitrogen, AST, ALT, NT-proBNP, hs-CRP levels, left ventricular (LV) and left atrium (LA) diameters and volumes but negatively correlated with LV ejection fraction (LVEF). It was found that these parameters were only closely related to NT-proBNP, LVEF and LA end-diastolic diameter. Conclusion: The serum Elabela level in patients with HFrEF is significantly increased, and this is closely related to NT-proBNP, LA end-diastolic diameter and LVEF. Increased Elabela value in patients with HFrEF is closely related to NYHA class-III patients.
Authors and Affiliations
Atilla Bulut, Armağan Acele, Yurdaer Dönmez, Hilmi Erdem Sümbül, Mevlüt Koç
Keywords
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- EP ID EP685153
- DOI 10.32596/ejcm.galenos.2020.11.059
- Views 169
- Downloads 0
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