Incretins: based therapy for type-2 Diabetes mellitus (T2DM)
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 2
Abstract
The treatment of type 2 diabetes mellitus is metformin and sulfonylurea (SU) as first-line anti- diabetic therapies for many years. It is the first line treatment though the combination results in a progressive decline in [beta]-cell function. There is 50% decline in [beta] cell by 3 years in diabetic patients so there is requirement of an additional pharmacological agent to maintain the glycosylated hemoglobin (HbA1c) <7.0% (UKPDS). Gliptins represent a novel class of agents that improve beta cell health and suppress glucagon, resulting in improved post-prandial and fasting hyperglycemia. They function by augmenting the incretin system (GLP-1 and GIP) preventing their metabolism by dipeptidyl peptidase-4 (DPP-4). They are not only efficacious but also safe as they do not cause significant hypoglycemia, and are weight neutral.
Authors and Affiliations
Sinha Ritesh kumar*, Alam Md Shadab, Kumar Pawan, Chandra Satish
Keywords
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