Incretins- in the care of Type 2 Diabetes Mellitus
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 4
Abstract
Abstract: The ever increasing incidence of Type2 Diabetes Mellitus (T2DM) in our population calls for a variety of agents to combat this disorder. T2DM is the resultant of Insulin deficiency or the reduced activity of available insulin. Incretins viz. "Glucose dependant Insulinotropic Polypeptide" (GIP) and "Glucagon like Polypeptide-1" (GLP-1) are the intestinal hormones secreted in response to ingestion of food and they increase the secretion of Insulin. Reduced efficacy of these hormones is seen in T2DM. This review analyses the role of Incretins in the therapy of T2DM. A number of studies have been going on to analyse and utilize the beneficial effects of these incretins. Some such studies are reviewed here to give an overall picture of the efficacy of incretins in the care of Type 2 diabetes mellitus. Results and discussion of these studies show that the bioactivity of incretins is short lived as they are easily degraded by the enzyme, Dipeptidyl peptidase 4. A drug that could prevent the incretin degradation and prolong their bioavailability was found to be beneficial. An incretin analogue that could increase the insulin secretion was also studied to be really useful in the treatment of T2DM. In Conclusion Incretin being the initiator of insulin secretion is effective in the care of Type 2 diabetes mellitus as synthetic analogues or as inhibitors of degradative enzyme, dipeptidyl peptidase 4. Keywords: Type2 Diabetes Mellitus, Incretin analogue, Dipeptidyl Peptidase4 inhibitor.
Authors and Affiliations
S. V. Mythili, K. Sumathi, A. Jamunarani
Keywords
Related Articles
- EP ID EP372594
- DOI -
- Views 80
- Downloads 0
Effect of Jatropha curcas Supplemented Diet on Broilers
Several authors have shown that farmers in Africa feed their poultry with partial or total dietary supplement, especially, diet based on local and cheaper ingredients in order to maximize profit, this however may have o...
Comparative Evaluation of the Effect of Water on Three Different Light Cured Composite Restorative Materials: An In Vitro Study
Abstract: Aims and Objectives of current to Evaluate the weight gain in three different light cured composites occurs due to water absorption. The composite restorative materials selected for this study included a micro-...
Analysis of Stability parameters in the bivoltine breeds of silkworm Bombyx mori L
Abstract: Genotype-environment (G-E) interaction and stability parameters were analyzed for ten each of oval and dumbbell silkworm bivoltine genotypes reared during three different seasons of the year. Quantitative econo...
Study on Effectiveness of Leukoreduction Filters
Leukocyte contamination during blood transfusion can cause many adverse effects, such as thetransmission of cell-associated infectious agents, febrile non-haemolytic reactions, graft-versus-hostdisease, and immunosuppres...
Effect of environmental factors on oospores shedding and diurnal periodicity in Sargassum vulgare C.Agardh. along the Visakhapatnam coastline, east coast of India
Sargassum vulgare C.Ag. was observed in Jodugullapalem of Visakhapatnam coast and brown alga was studied in respect of effect of environmental factors such as desiccation, salinity, Photon flux density, temperature, pho...