INDUCTION OF VASODILATION BY HYDROGEN PEROXIDE AND ITS APPLICATION IN EXERCISE SCIENCE
Journal Title: Biology of Sport - Year 2012, Vol 29, Issue 2
Abstract
Regular exercise or physical activity benefits the cardiovascular system, lowers mortality and morbidity, and is a particularly important factor for maintaining the health of blood vessels by improving the function of endothelial cells. Shear stress and increased metabolic rate caused by exercise induce vasodilation by generating endothelium-derived relaxing factors (EDRF) such as nitric oxide. In addition, some studies suggest that vasodilation is also induced by endothelium-derived hyperpolarizing factors (EDHF) and substances such as H2O2. Thus, we undertook this study to show that reactive oxygen species such as H2O2 that have not previously been investigated in the field of exercise science may induce vasodilation and an increase in blood pressure, and to provide information for application in the field of exercise science. In this review, we discuss reports on H2O2 published in the fields of basic science and exercise science while focusing on vasodilation induced by H2O2. H2O2 induces vasodilation by simultaneously increasing endothelial NOS (eNOS) and directly activating the Ca2+- activated K+ channels of vascular smooth muscle cells. A novel study should be conducted in the field of H2O2 as a factor of vasodilation via increased metabolic rate during exercise.
Authors and Affiliations
Dong-Jun Sung, Wi-Young So, Ho-Young Ryu, Hyun-Sung An, Kwang-Suk Cha
Keywords
Related Articles
- EP ID EP59097
- DOI -
- Views 123
- Downloads 0
THE EFFECT OF AEROBIC TRAINING ON SERUM ADIPONECTIN AND LEPTIN LEVELS AND INFLAMMATORY MARKERS OF CORONARY HEART DISEASE IN OBESE MEN
The aim of this study was to investigate the effect of 12 weeks of aerobic training on the serum levels of adiponectin and leptin and on inflammatory markers of coronary heart disease in obese men. Sixteen non-athlete ob...
DIFFERENT ENDURANCE CHARACTERISTICS OF FEMALE AND MALE GERMAN SOCCER PLAYERS
The aims of the present study were to assess gender differences regarding lactate threshold and intermittent shuttle run performance in female and male soccer players as well as to investigate the relationships between b...
Nutrition, activity behavior and body constitution in primary school children
Child and adolescent obesity currently affects at least 10-25% of the paediatric population in most developed countries. The BMI value is one of the most appropriate method of defining obesity and has a strong associatio...
EFFECTS OF TAEKWONDO TRAINING ON BONE MINERAL DENSITY OF HIGH SCHOOL GIRLS IN KOREA
The incidence of bone fractures has increased in the current decade due to osteoporosis. Bone mineral density (BMD), or the amount of mineralized bone, is an important determinant of risk for bone fractures. Bone mineral...
The effect of weight loss on serum concentrations of nitric oxide induced by short - term exercise in obese women
Objective: The aim of present study was to examine the effect of weight loss comprising regular moderate physical activity on resting serum concentrations of nitric oxide metabolites and exercise induced NO release. Mate...