Inflammatory mediators in chronic obstructive pulmonary disease: Review of related pathogenic mechanisms and efficacy of novel targeted therapies
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2015, Vol 32, Issue 6
Abstract
Chronic obstructive pulmonary disease (COPD) is a major global health problem which is increasing in prevalence and is now the fourth leading cause of death in the US. The pathophysiological mechanisms that control the development and progression of this disease are complex, but accumulating evidence indicates that chronic inflammation and innate and adaptive immune responses play key roles. Suppression of the inflammatory response is therefore a logical approach to the treatment of COPD. This is a review of the current literature on selected lymphocyte-associated mediators and pro-inflammatory cytokines that have been particularly implicated in the pathogenesis of the disease, with a discussion of the potential role of novel targeted therapies.
Authors and Affiliations
I. PANTAZOPOULOS, C. KAMPOLIS, K. AXIOTOU, A. LOUKERI, G. TSOUKALAS
Keywords
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