INFLUENCE OF DIFFERENT CHANGES ON BIOAVAILABILITY OF MEDICINE CHITOSANS ANTIPHLOGISTIC DRUGS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2008, Vol 0, Issue
Abstract
The increased adsorption of anti-inflammatory drugs on polymer with pH increased from 7.6 to 8.0 may be explained by the swelling properties of chitosan, which increase with increasing environmental pH to alkaline levels, in which the compound occurs in the form of emulsion, what increases the surface of the polymer and its sorption capacity. Basing on the above considerations, it can be stated that the investigated drug interacts with the polymer; the interaction is of an antagonistic character and consists in adsorption of the drugs on a polymer such as chitosan.
Authors and Affiliations
Jan Meler
Keywords
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- EP ID EP75952
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