Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

Journal Title: International Journal of Bioprinting - Year 2017, Vol 3, Issue 1

Abstract

One of the important constituents in tissue engineering is scaffold, which provides structural support and suitable microenvironment for the cell attachment, growth and proliferation. To fabricate micro/nano structures for soft tissue repair and three-dimensional (3D) cell culture, the key is to improve fibre-based scaffold fabrication. Electrohydrodynamic (EHD) jetting is capable of producing and orientating submicron fibres for 3D scaffold fabrication. In this work, an EHD-jetting system was developed to explore the relationship between vital processing parameters and fibre characteristics. In this study, polycaprolactone (PCL) solution prepared by dissolving PCL pellets in acetic acid was used to fabricate the scaffolds. The influence of voltage, motorized stage speed, solution feed rate, and solution concentration on fibre characteristics and scaffold pattern were studied. Morphology of the EHD-jetted PCL fibres and scaffolds were analysed using optical microscope images and scanning electron microscope (SEM) images. Multi-layer scaffolds with the varied coiled pattern were fabricated and analysed. Cell attachment and proliferation have to be investigated in the future by further cell culture studies on these multi-layer coiled scaffolds.

Authors and Affiliations

Hang Liu, Sanjairaj Vijayavenkataraman, Dandan Wang, Linzhi Jing, Jie Sun and Kai He

Keywords

Related Articles

A new design of an electrospinning apparatus for tissue engineering applications

The electrospinning technique is being widely explored in the biomedical field due to its simplicity to produce meshes and its capacity to mimic the micro-nanostructure of the natural extracellular matrix. For skin tissu...

The development of cell-adhesive hydrogel for 3D printing

Biofabrication has gained tremendous attention for manufacturing functional organs or tissues. To fabricate functional organs or tissues, it is necessary to reproduce tissue-specific micro to macro structures. Previously...

Bioprinting with pre-cultured cellular constructs towards tissue engineering of hierarchical tissues

The fabrication of physiologically active tissue constructs from various tissue elements are vital for establishing integrated bioprinting and transfer printing techniques as vital tools for biomedical research. Physiolo...

A Perspective on Using Machine Learning in 3D Bioprinting

Recently, three-dimensional (3D) printing technologies have been widely applied in industry and our daily lives. The term 3D bioprinting has been coined to describe 3D printing at the biomedical level. Machine learning i...

Advancing cancer research using bioprinting for tumor-on-a-chip platforms

There is an urgent for a novel approach to cancer research with 1.7 million new cases of cancer occurring every year in the United States of America. Tumor models offer promise as a useful platform for cancer research wi...

Download PDF file
  • EP ID EP678663
  • DOI -
  • Views 181
  • Downloads 0

How To Cite

Hang Liu, Sanjairaj Vijayavenkataraman, Dandan Wang, Linzhi Jing, Jie Sun and Kai He (2017). Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds. International Journal of Bioprinting, 3(1), -. https://www.europub.co.uk/articles/-A-678663