Influence of moderate physical training on the GH/IGF-1 axis in diabetic rats
Journal Title: Biology of Sport - Year 2006, Vol 23, Issue 3
Abstract
The influence of moderate physical training on serum growth hormone (GH), insulin-like growth factor –1 (IGF-1) and binding protein ( IGFBP-3) in experimental diabetic rats was investigated. Male Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Experimental diabetes was induced of Alloxan (35mg/b.w.) The training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5% b.w., during 6 weeks. Then, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, GH, IGF-1 and IGFBP-3. Samples of liver were used to evaluate glycogen, protein and DNA contents. The results were analyzed by ANOVA, and Bonferroni test and the significance level was set at 2.5%. Diabetes decreased serum GH, IGF-1, IGFBP-3 and liver glycogen stores in SD group. Physical training promoted increase in serum IGF-1 in both TC and TD groups (SC=82±15; TC=103±13; SD=77±16; TD=112± 29 ng/ml) and liver glycogen store in TD group when compared to SD (SC=5.2±1.2; TC= 6.2±1; SD=2±0.5; TD=5±1.8 mg/100mg). Therefore, physical training contributes to the increase in liver glycogen content and to rise of insulin-like growth factor level in diabetic rats. It was concluded that moderate physical training promotes important adaptations related to GH-IGF-1 axis in diabetic organisms.
Authors and Affiliations
RJ Gomes, FH Caetano, MAR Mello, E Luciano
Keywords
Related Articles
- EP ID EP58885
- DOI -
- Views 126
- Downloads 0
Minimum blood lactate and muscle protein of rats during swimming exercise
Few studies dealing with effort intensity during swimming exercise in rats have been reported in the literature. Recently, with the use of the lactate minimum test (LMT), our group estimated the minimum blood lactate (MB...
Histochemical responses of rats exercised in two weekly frequencies and ingesting standard or hypercaloric diet
This study investigated if overfed rats present morphological and histochemical muscle adaptation similar to normally fed, both submitted to two different weekly frequencies of training. Thirty male Wistar rats were fed...
High cycling cadence reduces carbohydrate oxidation at given low intensity metabolic rate
Cycling cadence (RPM)-related differences in blood lactate concentration (BLC) increase with increasing exercise intensity, whilst corresponding divergences in oxygen uptake (VO[sub]2[/sub]) and carbon dioxde production...
BENEFICIAL EFFECTS OF JUDO TRAINING ON BONE MINERAL DENSITY OF HIGH-SCHOOL BOYS IN KOREA
Bone mineralization is strongly stimulated by weight-bearing exercise during growth and development. Judo, an Olympic combat sport, is a well-known form of strenuous and weight-bearing physical activity. Therefore, the p...
The effect of anaerobic and aerobic tests on autonomic nervous system activity in healthy young athletes
INTRODUCTION. In the evaluation of physical efficiency in professional athletes two tests are used: Wingate test (WT) and incremental test for maximal oxygen uptake (IT). In the former anaerobic power is evaluated and in...