Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 1
Abstract
Background: The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg). Methods: Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu. Results: Single and subchronic administration of ZHA and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. ZHA alone administrated ip four times was active after the 1(st), 2(nd) and 3(rd) h from the carrageenan injection. Conclusions: ZHA enhanced the anti-inflammatory effect of ketoprofen.
Authors and Affiliations
Magdalena Gaweł, Tadeusz Librowski, Anna Lipkowska
Keywords
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