INFORMATIVENESS OF OXIDATIVE STRESS MARKERS IN OCCUPATIONAL EXPOSURE TO CARBON DISULFIDE
Journal Title: Българско списание за обществено здраве (Bulgarian Journal of Public Health) - Year 2014, Vol 0, Issue 4
Abstract
It is assumed that increased exposure to carbon disulfide (CS2) can lead to depletion of reduced glutathione peroxidase (GSH) and increased production of free radicals in the human body. Information on the effects of carbon disulfide on the oxidant-antioxidant system of the body is scarce. There have been studied 77 workers from synthetic fibers manufacturing plans exposed to different levels of carbon disulfide. The control group consists of 26 individuals without occupational exposure. Personal exposure is determined by personal dosimetry. Concentrations of reduced glutathione (GSH) in erythrocytes and the level of hydroperoxide radicals in capillary blood were measured as markers of oxidative stress. No significant correlation relationship was established between the level of exposure and concentrations of GSH and hydroperoxide radicals. There has been registered a statistically significant difference in the levels of GSH and hydroperoxide radicals when comparing the exposed persons according to their gender. In female workers GSH values are lower, and those of hydroperoxide radicals statistically significant (p = 0.018) - higher. There is a risk of oxidative stress in female workers, which might be associated with a variety of factors - gender, exposure, factors other than occupational exposure.
Authors and Affiliations
Tsveta Georgieva, Hristina Kopcheva, Teodor Panev, Todor Popov
Keywords
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