Inhibition of N-Acyl Homoserine Lactone Mediated Quorum Sensing in Pseudomonas aeruginosa by Phyllanthus emblica and Quercus infectoria
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
Quorum sensing (QS) is a process that enables bacteria to communicate using secretd signaling molecules called autoinducer. Pseudomonas aeruginosa an opportunistic pathogen in immune compromised patients is under the regulation of two different acyl homoserine lactones (AHLs) as the quorum signal molecules: N-3-oxododecanoyl homoserine lactone (3OC12) and N- butanoyl homoserine lactone (C4). Technology is required to block the very basic mechanism of bacterial communication that appear to control toxin production, adherence, motility, proteolysis and other virulence factors leading to pathogenecity. Natural products especially plants used in traditional medicines in different organisms are a promising source for deriving molecules that can potentially inhibit QS. Our objective was to screen for the QS inhibitory properties of 2 high quality herbs such as Phyllanthus emblica and Quercus infectoria. Effect of these extracts on P. aeruginosa virulence factors such as pyocyanin, total protease, elastase and biofilm formation were quantified by standard protocols. The result indicate that between and among the extracts of these two plants the aqueous extract of P. emblica showed greater reduced activity of pyocyanin synthesis, proteolytic enzymes elastolytic enzymes and biofilm formation.
Authors and Affiliations
Dr. Balakumar , Mahalakshmi. T , Jeyanthi. A
Keywords
Related Articles
- EP ID EP155206
- DOI -
- Views 119
- Downloads 0
Microencapsulation: A vital technique in novel drug delivery system
Novel drug delivery systems have several advantages over conventional multi dose therapy. Much research effort in developing novel drug delivery system has been focused on controlled release and sustained rele...
Formulation and Evalution of pH–Induced Povidone Iodine in Situ Gel for Oralthrush
Candida species have become a major opportunistic pathogen causing recurrent oral thrush and oropharyngeal candidiasis topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging act...
Study of antioxdant, antiinflammatory and woundhealing activity of extracts of Litsea glutinosa
Present work was undergone to investigate antioxidant and anti inflammatory and wound healing effects of Litsea glutinosa in rats. The aqueous extract of Litsea glutinosa (250 and 500 mg/kg body weight) was studied for a...
Inhibition of N-Acyl Homoserine Lactone Mediated Quorum Sensing in Pseudomonas aeruginosa by Phyllanthus emblica and Quercus infectoria
Quorum sensing (QS) is a process that enables bacteria to communicate using secretd signaling molecules called autoinducer. Pseudomonas aeruginosa an opportunistic pathogen in immune compromised patients is under the re...
Development and validation of RP-HPLC method for the estimation of nevirapine in bulk drug and tablets
A reverse phase high performance liquid chromatography [RP-HPLC] method has been developed for the estimation of Nevirapine in bulk drug and pharmaceutical dosage forms. The quantification was carried out on Octa Decyl S...