Inhibition of Pro-Inflammatory Cytokine TNF-α by Boerhaavia diffusa (L.) in Liposaccharide stimulated Human THP-1 cells
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 6
Abstract
The production and release of proinflammatory cytokines such as Tumor necrotic factor-α (TNF- α), Interleukin-1β and Iinterleukin-6 from monocytes/macrophages play critical role in the pathogenesis of chronic inflammatory diseases and immune response. Boerhaavia diffusa L is a medicinal plant in the Indian traditional system known as Rasayana (Indigenous plants with immunomodulatory activity) and an important source of immunomodulators. In present study, the antiinflammatory activity of herbal immune modulator Boerhaavia diffusa L was studied by evaluating the inhibition of Lipopolysaccharide stimulated TNF-α secretion using human Monocytic THP-1 cells. Differentiation of the human monocytic cell THP-1 into macrophage-like cells was induced by exposure of the cells to Phorbol Myristate Acetate. When cells were pre-incubated with Methanolic extract of Boerhaavia diffusa L for 4 hrs and then stimulated with lipopolysaccharide for 12 hrs, secretion of tumor necrosis factor- α was significantly decreased compared to control. The present study has shown that the Boerhaavia diffusa L inhibits the production and release of proinflammatory cytokines, TNF-α from monocytes/macrophages which play critical role in the pathogenesis of chronic inflammatory diseases and hence this could be the probable mechanism, by which this immunomodulatory herbal plant extracts possess anti-inflammatory activity.
Authors and Affiliations
Jay H. Shah| Faculty of Pharmacy, Hemchandracharya North Gujarat University, Patan, India, I. S. Anand| Faculty of Pharmacy, Hemchandracharya North Gujarat University, Patan, India, K. K. Shah| Faculty of Pharmacy, Hemchandracharya North Gujarat University, Patan, India
Keywords
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- EP ID EP16047
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(6).2820-2
- Views 369
- Downloads 24
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