Innovation of a Novel Therapeutic Modality for Treatment of Osteoarthritis of Knee with Autologous Adipose Derived Stromal Vascular Fraction (AD-SVF)
Journal Title: IP International Journal of Orthopaedic Rheumatology - Year 2017, Vol 3, Issue 2
Abstract
Background: Adipose tissue derived stromal vascular fraction is crude heterogeneous mixture of different cell population. SVF possess potential to translate into oesteogenic and chondrogenic lineage. We designed a pilot study to assess safety and efficacy of autologous adipose derived stromal vascular fraction (AD-SVF) in 25 patients (50 knees) with both the knees having osteoarthritis. Methods: Patients were selected based on selection criteria. Lipoaspiration from the lower abdomen was done. The lipoaspirate was processed to obtain SVF. The intra-articular injection of SVF and PRP was given. Clinical outcomes were assessed with WOMAC, KSS, and VAS scores and radiologically at the interval of 6 weeks, 6 months and 1 year. Results: The safety of AD-SVF was confirmed as there were no adverse reactions related to therapy. Patients exhibited rapid and progressive improvement of WOMAC, KSS and VAS Score by 1 year. MRI studies did not show radiological evidence of cartilage. Conclusions: AD-SVF therapy is safe & efficacious alternative treatment for knee osteoarthritis. The intervention is simple, minimally invasive, require minimal hospitalization and surgery.
Authors and Affiliations
Prashant Kshatriy, Anant Marathe, Jaymesh Thadani, Shivani Vakodikar, Rajni Vyas, Ramesh Bhonde
Keywords
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- EP ID EP299260
- DOI 10.18231/2455-6777.2017.0013
- Views 74
- Downloads 0
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